Drug releasing biodegradable fiber for delivery of therapeutics
First Claim
1. A method of manufacturing a fiber comprising,dissolving a biodegradable polymer in a first solvent to form a polymer solution, wherein said first solvent is poorly miscible in water;
- preparing a solution comprising a gel or hydrogel;
promoting the internal gelation of the gel or hydrogel using a divalent cation;
co-extruding the polymer solution and the solution comprising the gel or hydrogel into a coagulating bath, wherein the coagulating bath comprises a second solvent that is highly miscible with the first solvent; and
forming at least one bicomponent fiber having a core-in sheath configuration, wherein the fiber comprises a first component and a second component, and wherein said first component is a biodegradable polymer and said second component comprises a gel or a hydrogel.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The invention also relates to methods of manipulating the rate of therapeutic agent release by changing both the biodegradable polymer properties as well as altering the properties of the incorporated gel or hydrogel.
-
Citations
11 Claims
-
1. A method of manufacturing a fiber comprising,
dissolving a biodegradable polymer in a first solvent to form a polymer solution, wherein said first solvent is poorly miscible in water; -
preparing a solution comprising a gel or hydrogel; promoting the internal gelation of the gel or hydrogel using a divalent cation; co-extruding the polymer solution and the solution comprising the gel or hydrogel into a coagulating bath, wherein the coagulating bath comprises a second solvent that is highly miscible with the first solvent; and forming at least one bicomponent fiber having a core-in sheath configuration, wherein the fiber comprises a first component and a second component, and wherein said first component is a biodegradable polymer and said second component comprises a gel or a hydrogel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
Specification