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Drug releasing biodegradable fiber for delivery of therapeutics

  • US 8,062,654 B2
  • Filed: 02/03/2006
  • Issued: 11/22/2011
  • Est. Priority Date: 08/06/1999
  • Status: Expired due to Term
First Claim
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1. A method of manufacturing a fiber comprising,dissolving a biodegradable polymer in a first solvent to form a polymer solution, wherein said first solvent is poorly miscible in water;

  • preparing a solution comprising a gel or hydrogel;

    promoting the internal gelation of the gel or hydrogel using a divalent cation;

    co-extruding the polymer solution and the solution comprising the gel or hydrogel into a coagulating bath, wherein the coagulating bath comprises a second solvent that is highly miscible with the first solvent; and

    forming at least one bicomponent fiber having a core-in sheath configuration, wherein the fiber comprises a first component and a second component, and wherein said first component is a biodegradable polymer and said second component comprises a gel or a hydrogel.

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