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Stimuli-responsive systems for controlled drug delivery

  • US 8,062,668 B2
  • Filed: 03/31/2009
  • Issued: 11/22/2011
  • Est. Priority Date: 12/17/2002
  • Status: Active Grant
First Claim
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1. A material for delivery of a therapeutic agent in response to an indicator, comprising:

  • conjugates that include a therapeutic agent covalently linked to a polymer, wherein the polymer includes two or more indicator analogs;

    polyfunctional cross-linking agents that cross-link conjugates by non-covalently interacting with indicator analogs on different conjugates, wherein;

    the material is insoluble in the absence of an indicator that competes with the indicator analogs for non-covalent interactions with the cross-linking agents, andconjugates are released from the material in the presence of the indicator at a rate that depends on the concentration of the indicator, wherein;

    the indicator is glucose; and

    the indicator analogs comprise glucose and/or mannose residues.

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