Stimuli-responsive systems for controlled drug delivery
First Claim
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1. A material for delivery of a therapeutic agent in response to an indicator, comprising:
- conjugates that include a therapeutic agent covalently linked to a polymer, wherein the polymer includes two or more indicator analogs;
polyfunctional cross-linking agents that cross-link conjugates by non-covalently interacting with indicator analogs on different conjugates, wherein;
the material is insoluble in the absence of an indicator that competes with the indicator analogs for non-covalent interactions with the cross-linking agents, andconjugates are released from the material in the presence of the indicator at a rate that depends on the concentration of the indicator, wherein;
the indicator is glucose; and
the indicator analogs comprise glucose and/or mannose residues.
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Abstract
A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is correlated with a local concentration of an indicator, and the therapeutic agent is released as the cross-linked polymer degrades.
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Citations
25 Claims
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1. A material for delivery of a therapeutic agent in response to an indicator, comprising:
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conjugates that include a therapeutic agent covalently linked to a polymer, wherein the polymer includes two or more indicator analogs; polyfunctional cross-linking agents that cross-link conjugates by non-covalently interacting with indicator analogs on different conjugates, wherein; the material is insoluble in the absence of an indicator that competes with the indicator analogs for non-covalent interactions with the cross-linking agents, and conjugates are released from the material in the presence of the indicator at a rate that depends on the concentration of the indicator, wherein; the indicator is glucose; and the indicator analogs comprise glucose and/or mannose residues. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification