Silicone based membranes for use in implantable glucose sensors
First Claim
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1. An implantable analyte sensor, comprising:
- a membrane comprising a blend, the blend comprising a dimethyl-siloxane and methylhydrogen-siloxane copolymer and a poly(ethylene oxide) and poly(propylene oxide) copolymer;
wherein the membrane is adapted to permit diffusion of both an analyte and oxygen therethrough.
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Abstract
Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
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Citations
35 Claims
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1. An implantable analyte sensor, comprising:
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a membrane comprising a blend, the blend comprising a dimethyl-siloxane and methylhydrogen-siloxane copolymer and a poly(ethylene oxide) and poly(propylene oxide) copolymer; wherein the membrane is adapted to permit diffusion of both an analyte and oxygen therethrough. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An implantable analyte sensor, comprising:
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a membrane comprising a blend, the blend comprising a silicone polymer and a triblock poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) copolymer; wherein the membrane is adapted to control a flux of both an analyte and oxygen therethrough. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A membrane for use in an analyte sensor, comprising:
a blend comprising; a silicone polymer; and a poly(ethylene oxide) and poly(propylene oxide) copolymer, wherein at least a portion of the copolymer is cross-linked; and wherein the membrane is adapted to permit diffusion of both the analyte and oxygen therethrough. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. An implantable analyte sensor, comprising:
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an enzyme layer comprising an enzyme; a bioprotective layer positioned between the enzyme layer and tissue adjacent to the sensor when implanted, wherein the bioprotective layer comprises a blend comprising a silicone polymer and a poly(ethylene oxide) and poly(propylene oxide) copolymer; and an electroactive surface configured to measure the analyte or product of reaction of the enzyme with the analyte. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification