Methods and apparatus for effectuating a lasting change in a neural-function of a patient

• US 8,065,012 B2
• Filed: 08/06/2007
• Issued: 11/22/2011
• Est. Priority Date: 07/13/2000
• Status: Expired due to Fees

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Inventors: Morgan, Carlton B., Firlik, Andrew D., Gliner, Bradford Evan, Levy, Alan J., Firlik, Katrina S., Balzer, Jeffrey
• Primary Examiner(s): Getzow; Scott
• Assistant Examiner(s): ALTER, ALYSSA MARGO
• Application Number:
  US11/834,650
• Publication Number:
  US 20080161881A1
• Time in Patent Office: 1,569 Days
• Field of Search: 607/45, 607/46, 607/116, 600/378
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36103 Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
• CPC Class Codes: A61N 1/37514 Brain implants
• CPC Class Codes: A61N 1/37518 Anchoring of the implants, e.g. fixation
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Disclosed are several apparatuses and methods for applying intracranial electrical stimulation to treat or enhance the neural function of the patient. In accordance with the invention, intracranial electrical stimulation can be administered to treat brain damage, brain disease, and/or brain disorders. Additionally the intracranial electrical stimulation can be applied to a normal healthy brain to enhance neural-function or control sensory functions. The electrical stimulation site(s) of the brain are located where neuroplasticity is occurring, expected to occur, or in a region where neuroplasticity is not occurring. The intracranial stimulation is expected to produce a lasting effect on the intended neural activity by applying subthreshold stimulation to the increasing the resting membrane potential of the neurons at the stimulation site.

Claims

1. A method of effectuating a neural-function of a patient, comprising:

selecting a stimulation site on the cortex of the brain of the patient by a) generating neural activity by having the patient perform a neural-function task; and

b) selecting areas of the brain having the highest intensity or greatest alteration in neural activity during or after the task;

positioning at least a first electrode at the stimulation site; and

applying electrical stimulation directly to the stimulation site via the electrode.

2. The method of claim 1 wherein the stimulation site comprises a normal region of the brain where the intended activity is expected to occur, a different region of the brain than the normal region due to the brain recruiting areas to perform the function or a combination thereof.

3. The method of claim 1 wherein the neural-function task is performing a task or thinking about performing a task.

4. The method of claim 1 wherein selecting a stimulation site includes using a neurofunctional localization device.

5. The method of claim 4 wherein using a neurofunctional localization device includes using fMRI techniques.

6. The method of claim 4 wherein using a neurofunctional localization device includes using imaging techniques.

7. The method of claim 4 wherein using a neurofunctional localization device includes using EEG techniques.

8. The method of claim 4 wherein using a neurofunctional localization device includes using PET techniques.

9. The method of claim 1 wherein applying electrical stimulation includes applying electrical stimulation that affects maladaptive neuroplasticity at the stimulation site.

10. The method of claim 1 wherein the patient has been diagnosed with depression and the stimulation site is selected to treat the depression.

11. The method of claim 1 wherein positioning an electrode comprises positioning a surface electrode under the skull directly on the dura.

12. The method of claim 1 wherein the selected stimulation site comprises a site where neuroplasticity is associated with the neural activity.

13. The method of claim 12 wherein applying electrical stimulation to the stimulation site comprising neuroplasticity enhances a change in neural activity to assist the brain in performing a particular function.

14. The method of claim 12 wherein neuroplasticity is induced or enhanced by applying electrical stimulation to the stimulation site.

15. A method of effectuating a neural-function of a patient, comprising:

selecting a stimulation site on the cortex of the brain of the patient by a) generating neural activity by having the patient perform a neural-function task; and

b) selecting areas of the brain having highest intensity or greatest alteration in the neural activity during or after the neural-function task;

positioning at least a first electrode at the stimulation site such that the at least first electrode is positioned under the skull and on the dura directly over the stimulation site; and

applying electrical stimulation directly to the stimulation site via the at least first electrode.

16. The method of claim 15 wherein the stimulation site is further defined by estimating a location that the brain may recruit neurons to carry out the neural activity that was previously performed by a damaged portion of the brain.

17. The method of claim 15 wherein the patient has been diagnosed with a memory disorder and the stimulation site is selected to treat the memory disorder.

18. A method of treating depression or a mood disorder in a patient, comprising:

selecting a stimulation site on the cortex of the brain of the patient by a) generating neural activity by having the patient perform a neural-function task; and

b) selecting areas of the brain having highest intensity or greatest alteration in the neural activity during or after the neural-function task; and

applying electrical stimulation directly to the stimulation site via at least one electrode to treat the depression, wherein the at least one electrode is positioned under the skull and on the dura directly over the stimulation site.