Implantable apparatus for administering a therapeutic agent into tissue

• US 8,066,695 B2
• Filed: 04/28/2009
• Issued: 11/29/2011
• Est. Priority Date: 10/06/2003
• Status: Expired due to Fees

• Current Assignee: ActiveO, Inc.
• Original Assignee: Ceramatec, Inc.
• Inventors: Murphy, Kieran P., Muto, Mario
• Primary Examiner(s): STIGELL, THEODORE J
• Application Number:
  US12/431,089
• Publication Number:
  US 20090254021A1
• Time in Patent Office: 945 Days
• Field of Search: 604/890.1, 604/891.1, 604 23- 26, 60428801-28804, 604/93.01
• US Class Current: 604/891.1
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 2005/3114 Filling or refilling
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0216 Ozone
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 25/065 Guide needles
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids

Abstract

An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

Claims

1. An apparatus for generation and administration of medical ozone comprising:

an implantable ozone generator for generating the medical ozone;

an implantable chamber in communication with the ozone generator for holding said medical ozone generated from the generator;

an implantable catheter for connecting said chamber to an area for administration of said medical ozone;

a separate, external switchable power supply adapted to be disposed outside of the patient; and

wherein, when the power supply is switched on, the ozone generator is activated to fill the implantable chamber with the medical ozone which is thereafter delivered to the area through the implantable catheter.

2. The apparatus of claim 1, wherein said ozone generator is in communication with a supply of oxygen.

3. The apparatus of claim 1, wherein said medical ozone comprises a ratio of ozone (0₃) to oxygen (0₂).

4. The apparatus of claim 3, wherein said ratio of ozone to oxygen is about 1 μ

g/ml.

5. The apparatus of claim 3, wherein said ratio of ozone to oxygen is about 10 μ

g/ml.

6. The apparatus of claim 3, wherein said ratio of ozone to oxygen is about 20 μ

g/ml.

7. The apparatus of claim 3, wherein said ratio of ozone to oxygen is about 30 μ

g/ml.

8. The apparatus of claim 3, wherein said ratio of ozone to oxygen is about 40 μ

g/ml.

9. The apparatus of claim 3, wherein said ratio of ozone to oxygen is about 50 μ

g/ml.

10. The apparatus of claim 3, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μ

g/ml and about 90 μ

g/ml.

11. The apparatus of claim 3, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 80 μ

g/ml.

12. The apparatus of claim 3, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μ

g/ml and about 70 μ

g/ml.

13. The apparatus of claim 3, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 34 μ

g/ml.

14. The apparatus of claim 3, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μ

g/ml to about 28 μ

g/ml.

15. An apparatus for generation and administration of medical ozone inside a patient comprising:

an implantable chamber for holding said medical ozone;

an implantable catheter for connecting said chamber to an area for administration of said medical ozone;

an implantable power supply;

an implantable supply of oxygen;

an implantable medical ozone generator in communication with said chamber and said supply of oxygen, said generator operably connected to said power supply for producing said medical ozone comprising a ratio of ozone to oxygen, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 34 μ

g/ml.

a wireless switching means disposed outside of the patient, said switching means connected to said power supply such that when said switching means is activated said medical ozone generator generates said medical ozone and fills said chamber therewith, said medical ozone thereafter delivered to the area through the implantable catheter.

16. The apparatus of claim 15, wherein the switching means comprises a magnetic switch.