Implantable medical devices incorporating plasma polymerized film layers and charged amino acids

• US 8,067,023 B2
• Filed: 07/15/2005
• Issued: 11/29/2011
• Est. Priority Date: 06/21/2002
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Michal, Eugene T., Claude, Charles D.
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US11/183,030
• Publication Number:
  US 20050249777A1
• Time in Patent Office: 2,328 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/114 Nitric oxide, i.e. NO
• CPC Class Codes: A61L 2300/25 Peptides having up to 20 amino acids in a defined sequence
• CPC Class Codes: A61L 31/047 Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
• CPC Class Codes: A61L 31/084 Carbon; Graphite
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B05D 1/62 Plasma-deposition of organic layers plasma deposition in general C23C14/00, C23C16/00
• CPC Class Codes: B05D 2350/60 Adding a layer before coating

Abstract

An implantable medical device, such as a stent, is disclosed comprising an amino acid or a polypeptide bonded to a plasma polymerized film layer formed on the device. A method of manufacturing the same is also disclosed.

Claims

1. A stent comprising a plasma polymerized film layer and a substance comprising a charged amino acid group, wherein the substance is attached to the plasma polymerized film layer,

wherein the attachment comprises an ionic bond between the substance and the plasma polymerized film layer.

2. The stent of claim 1, wherein the substance comprises L-arginine, D-arginine, L-lysine, D-lysine, δ

-guanidino-α

-aminobutyric acid, or combinations thereof.

3. The stent of claim 1, wherein the amino acid group comprises a positive charge.

4. The stent of claim 1, wherein the amino acid group comprises a negative charge.

5. The stent of claim 1, wherein the substance comprises chitosan.

6. The stent of claim 1, wherein the substance comprises a drug.

7. The stent of claim 1, wherein the stent comprises a carbon deposit on the surface of the stent, and wherein the carbon deposit is attached to the plasma polymerized film layer.

8. A stent comprising a plasma polymerized film layer and a substance comprising an amino acid, wherein the substance is chemically bonded to the plasma polymerized film layer,

wherein the plasma polymerized film layer is derived from an organic substance having a carboxyl group.

9. The stent of claim 8, wherein the organic substance comprises a low molecular weight organic acid or a combination of low molecular weight organic acids.

10. The stent of claim 9, wherein the organic substance comprises a component selected from a group consisting of acrylic acid, propionic acid, butyric acid, valeric acid, methacrylic acid, and combinations thereof.

11. The stent of claim 8, wherein the substance comprises L-arginine, D-arginine, L-lysine, D-lysine, δ

-guanidino-α

-aminobutyric acid, or a mixture thereof.

12. The stent of claim 11, wherein the L-arginine is releasable for local delivery in a patient.

13. The stent of claim 8, wherein a surface of the stent on which the plasma polymerized film layer is deposited includes a carbon deposit, wherein the plasma polymerized film layer is formed on and bonded to the carbon deposit.