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Chemically modified small molecules

  • US 8,067,431 B2
  • Filed: 02/22/2010
  • Issued: 11/29/2011
  • Est. Priority Date: 12/16/2003
  • Status: Active Grant
First Claim
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1. A method of treating a patient in need of an opioid antagonist, comprising:

  • administering to the patient an oral dosage form comprising a compound selected from the group consisting of6-CH3

    (OCH2CH2)5

    O-naloxol;

    6-CH3

    (OCH2CH2)6

    O-naloxol;

    6-CH3

    (OCH2CH2)7

    O-naloxol;

    6-CH3

    (OCH2CH2)8

    O-naloxol; and

    6-CH3

    (OCH2CH2)9

    O-naloxol;

    or a pharmaceutically acceptable salt thereof, wherein the compound is an α

    -6 isomer, a β

    -6 isomer or a mixture of α

    -6 and β

    -6 isomers.

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