Chemical detection method and system

• US 8,067,731 B2
• Filed: 02/20/2009
• Issued: 11/29/2011
• Est. Priority Date: 03/08/2008
• Status: Expired due to Fees

• Current Assignee: Teledyne Detcon, Inc. (Teledyne Technologies Incorporated)
• Original Assignee: Scott Technologies, Inc. (3M Company)
• Inventors: Matyjaszczyk, Maciej (Matthew) Stanislaw, Staubs, Amy Elizabeth
• Primary Examiner(s): Souw; Bernard E
• Application Number:
  US12/390,305
• Publication Number:
  US 20090224150A1
• Time in Patent Office: 1,012 Days
• Field of Search: 250281-284, 250/287, 250292-295, 250/299, 250/396.R, 250/397, 250/526
• US Class Current: 250/295
• CPC Class Codes: G01N 27/623 combined with mass spectrometry
• CPC Class Codes: H01J 49/00 Particle spectrometers or separator tubes
• CPC Class Codes: H01J 49/004 Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn

Abstract

A system and method for detecting an analyte of interest in a sample is provided. The method includes passing a set of ions obtained from the sample through an ion mobility spectrometer to filter out ions that are not ions of interest and to generate an ion mobility spectrum. A mass spectrum of at least some of the ions is generated using a mass spectrometer. The method also includes determining that the analyte of interest is in the sample when peaks of interest are found in one or more of the ion mobility spectrum and the mass spectrum, and the peaks of interest follow a predetermined pattern of peaks associated with the analyte of interest or are confirmed by ion mobility spectrometry.

Claims

1. A method for detecting an analyte of interest in a sample, the method comprising:

passing a set of ions obtained from the sample through an ion mobility spectrometer to filter out ions that are not ions of interest and to generate an ion mobility spectrum;

generating a mass spectrum of at least some of the ions using a mass spectrometer;

determining that the analyte of interest is in the sample when peaks of interest are found in one or more of the ion mobility spectrum and the mass spectrum, and the peaks of interest follow a predetermined pattern of peaks associated with the analyte of interest; and

confirming a presence of at least one of the peaks of interest by obtaining an initial portion of the at least one of the peaks of interest using a first dispersion voltage and a first compensation voltage in the ion mobility spectrometer and obtaining an additional portion of the at least one of the peaks of interest using at least one of a different, second dispersion voltage or a different, second compensation voltage in the ion mobility spectrometer.

2. The method of claim 1, wherein the passing operation comprises passing the ions through a plurality of ion mobility spectrometers connected in series with one another.

3. The method of claim 1, wherein the generating operation comprises passing the ions through a plurality of mass spectrometers connected in series with one another.

4. The method of claim 1, wherein the peaks of interest comprise one or more of a molecular peak created from ions associated with a molecule in the analyte of interest, an ion fragment peak created from an ion fragment obtained from the analyte of interest, a dopant-related peak created from a chemical species formed from a reaction between the analyte of interest and a dopant, or any other peak representing the analyte of interest.

5. The method of claim 4, wherein the determining operation comprises determining that the analyte of interest is in the sample when the peaks of interest include the molecular peak and at least one of the ion fragment peak, the dopant-related peak, or any other peak related to the analyte of interest in the mass spectrum.

6. A system for detecting an analyte of interest in a sample, the system comprising:

an ion mobility spectrometer configured to receive a set of ions obtained from the sample to filter out ions that are not ions of interest and to generate an ion mobility spectrum;

a mass spectrometer connected in series with the ion mobility spectrometer to receive at least some of the ions from the ion mobility spectrometer and to generate a mass spectrum of the ions received from the ion mobility spectrometer; and

a computing device for determining that the analyte of interest is in the sample when peaks of interest are found in one or more of the ion mobility spectrum and the mass spectrum and the peaks of interest follow a predetermined pattern of peaks associated with the analyte of interest,

wherein the ion mobility spectrometer is configured to confirm a presence of at least one of the peaks of interest by obtaining an initial portion of the at least one of the peaks of interest using a first dispersion voltage and a first compensation voltage and obtaining an additional portion of the peak of interest using at least one of a different, second dispersion voltage or a different, second compensation voltage.

7. The system of claim 6, further comprising at least one additional ion mobility spectrometer connected in series with the ion mobility spectrometer and the mass spectrometer, the ions passing through each of the ion mobility spectrometer and the additional ion mobility spectrometer to filter out ions that are not ions of interest and to generate an ion mobility spectrum.

8. The system of claim 6, further comprising at least one additional mass spectrometer connected in series with the ion mobility spectrometer and the mass spectrometer, the ions received by each of the mass spectrometer and the additional mass spectrometer to generate a mass spectrum.

9. The system of claim 6, wherein the peaks of interest comprise one or more of a molecular peak created from ions associated with a molecule in the analyte of interest, an ion fragment peak created from an ion fragment obtained from the analyte of interest, a dopant-related peak created from a chemical species formed from a reaction between the analyte of interest and a dopant, or any other peak related to the analyte of interest.

10. The system of claim 9, wherein the computing device determines that the analyte of interest is in the sample when the peaks of interest include the molecular peak and at least one of the ion fragment peak, the dopant-related peak, and or any other peak related to the analyte of interest in the mass spectrum.

11. A computer-readable storage medium for a computing device configured to determine if an analyte of interest is in a sample, the computer-readable storage medium comprising instructions to direct the computing device to:

generate one or more of an ion mobility spectrum and a mass spectrum of ions obtained from the sample;

detect peaks of interest in one or more of the ion mobility spectrum and the mass spectrum;

determine if the peaks of interest follow a predetermined pattern of peaks associated with the analyte of interest;

confirm the presence of the peak of interest by obtaining a portion of the peak of interest at a first dispersion voltage and a first compensation voltage in an ion mobility spectrometer and obtaining an additional portion of the peak of interest using one or more of a different, second dispersion voltage or a different, second compensation voltage in the ion mobility spectrometer; and

provide a notification that the analyte of interest is in the sample when the peaks of interest follow the predetermined pattern of peaks.

12. The computer-readable storage medium of claim 11, wherein the peaks of interest comprise one or more of a molecular peak created from ions associated with a molecule in the analyte of interest, an ion fragment peak created from an ion fragment obtained from the analyte of interest, a dopant-related peak created from a chemical species formed from a reaction between the analyte of interest and a dopant, or any other peak related to the analyte of interest.

13. The computer-readable storage medium of claim 11, wherein the instructions direct the computing device to provide the notification if one or more of the peaks of interest are in the ion mobility spectrum, the predetermined peak pattern is followed or a presence of at least one of the peaks of interest in the ion mobility spectrum is confirmed.

14. The computer-readable storage medium of claim 13, wherein the instructions direct the computing device to provide the notification if a molecular peak of interest and at least one of an ion fragment peak of interest, a dopant-related peak of interest, or any other peak related to the analyte of interest are found in the mass spectrum, and the predetermined peak pattern is followed.

15. The computer-readable storage medium of claim 13, wherein the instructions direct the computing device to confirm the presence of the peak of interest by obtaining the peak of interest using a first electric field in the ion mobility spectrometer and obtaining the peak of interest or a different peak of interest using a second electric field in the ion mobility spectrometer, the second electric field being at least four times greater than the first electric field.

16. The computer-readable storage medium of claim 11, wherein the peaks of interest comprise a molecular peak of interest and at least one of an ion fragment peak of interest, a dopant-related peak of interest, or another peak of interest detected in the ion mobility spectrum, further wherein the instructions direct the computing device to confirm a presence of the peaks of interest in the ion mobility spectrum.

17. A system for detecting an analyte of interest in a sample, the system comprising:

a first field compensation ion mobility spectrometer (“

first FCIMS”

) configured to receive a set of ions generated from the sample and filtering filter out ions from the set that are not ions of interest and generating a first ion mobility spectrum;

a second field compensation ion mobility spectrometer (“

second FCIMS”

) connected with the first FCIMS, the second FCIMS receiving ions from the first FCIMS to generate a second ion mobility spectrum; and

a computing device for analyzing the first and second ion mobility spectra to determine a presence of the analyte of interest in the sample when peaks of interest are in the first and second ion mobility spectra.

18. The system of claim 17, wherein the peaks of interest comprise one or more of a molecular peak created from ions associated with a molecule in the analyte of interest, an ion fragment peak created from an ion fragment obtained from the analyte of interest, a dopant-related peak created from a chemical species formed from a reaction between the analyte of interest and a dopant, or any other peak related to the analyte of interest.

19. The system of claim 17, wherein the computing device determines the presence of the analyte of interest when the peaks of interest follow a predetermined pattern of peaks associated with the analyte of interest.

20. The system of claim 17, wherein the computing device determines the presence of the analyte of interest when the peaks of interest are confirmed by at least one of the first and second FCIMS.

21. The system of claim 20, wherein the at least one of the first and second FCIMS confirms the presence of the analyte of interest by obtaining a first portion of at least one of the peaks of interest using a first electric field and obtaining an additional portion of the peak of interest using a second electric field.

22. The system of claim 17, wherein each of the first and second FCIMS comprise opposing electrode plates configured to generate an electric field through which the ions pass before being detected or filtered by the first and second FCIMS, wherein the electrode plates of the first FCIMS are separated by a different distance than the electrode plates of the second FCIMS.