Method for estimating cardiac pressure using parameters derived from impedance signals detected by an implantable medical device

• US 8,068,907 B2
• Filed: 08/20/2007
• Issued: 11/29/2011
• Est. Priority Date: 01/11/2000
• Status: Expired due to Fees

• Current Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Original Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Inventors: Eigler, Neal L., Whiting, James S., Mann, Brian
• Primary Examiner(s): Hindenburg; Max
• Assistant Examiner(s): TOWA, RENE T
• Application Number:
  US11/842,133
• Publication Number:
  US 20080039821A1
• Time in Patent Office: 1,562 Days
• Field of Search: 600/486, 600/547, 600/587, 324/600, 607 6- 23
• US Class Current: 600/547
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/02156 Calibration means
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

A method of monitoring pressure within a medical patient, includes measuring an actual pressure in a medical patient in a first time period; measuring an indicator of the actual pressure in the first time period, wherein the indicator is derived from an electrical signal of the patient'"'"'s heart; determining a correlative relationship between the actual pressure and the indicator, wherein both the actual pressure and the indicator are obtained in the first time period; measuring the indicator in a second time period; and determining the actual pressure in the second time period based on the correlative relationship obtained in the first time period and the indicator obtained in the second time period.

Claims

1. A method for estimating cardiac pressure within a patient using an implantable medical device, the method comprising:

measuring an electrical parameter across the thoracic cavity of a patient, the electrical parameter being associated with cardiac tissues of the patient, wherein the electrical parameter is indicative of cardiac pressure;

estimating cardiac pressure within the patient by applying predetermined conversion factors to the measured electrical parameter; and

signaling a user to calibrate an implanted pressure sensor based upon the estimated cardiac pressure.

2. The method of claim 1 wherein the electrical parameter comprises an electrical impedance.

3. The method of claim 2 wherein the electrical parameter comprises thoracic electrical impedance.

4. The method of claim 1 further including controlling therapy based on estimated cardiac pressure.

5. The method of claim 1 wherein the implantable device is equipped with an implantable drug pump and wherein drug therapy is controlled based on estimated cardiac pressure.

6. The method of claim 1 further including detecting heart failure based on estimated cardiac pressure.

7. The method of claim 6 wherein the implantable device is equipped with an implantable warning device and wherein a warning is generated upon detection of heart failure.

8. The method of claim 6 wherein the implantable device is equipped to transmit signals to an external display device and wherein the warning is transmitted to the external device.

9. The method of claim 1 wherein the implantable device is equipped to transmit signals to an external display device and wherein estimated cardiac pressure values are transmitted to the external device.

10. The method of claim 1 wherein the predetermined conversion factors are automatically determined from historical pressure data and historical parameter data.

11. The method of claim 1 wherein the predetermined conversion factors are stored within the implantable medical device.

12. The method of claim 1 further comprising calibrating an implanted pressure sensor based upon the estimated cardiac pressure.

13. The method of claim 1 further comprising signaling a user to calibrate an implanted pressure sensor based upon a difference between the estimated cardiac pressure and a pressure signal provided by an implanted pressure sensor.

14. The method of claim 1 further comprising measuring a pressure signal indicative of the cardiac pressure with the implanted pressure sensor.

15. The method of claim 1 wherein said signaling a user to calibrate an implanted pressure sensor comprises instructing the user to perform a Valsalva calibration.

16. The method of claim 1 wherein said signaling a user to calibrate an implanted pressure sensor comprises instructing the user to contact a physician.

17. The method of claim 1 wherein said signaling a user to calibrate an implanted pressure sensor comprises instructing the user to go to a physician'"'"'s office.