Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony

• US 8,068,908 B2
• Filed: 11/30/2005
• Issued: 11/29/2011
• Est. Priority Date: 11/30/2005
• Status: Expired due to Fees

• Current Assignee: St. Jude Medical AB (Abbott Laboratories)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories)
• Inventors: Nilsson, Kenth, Hedberg, Sven-Erik, Järverud, Karin
• Primary Examiner(s): Manuel; George
• Assistant Examiner(s): WIELAND, ROBERT N
• Application Number:
  US12/094,543
• Publication Number:
  US 20080294216A1
• Time in Patent Office: 2,190 Days
• Field of Search: 600/437, 600/445, 600/481, 600/508, 600/509, 600/536, 607/9, 607/17, 607/18, 607/19
• US Class Current: 607/9
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone

Abstract

In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location of a heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the first sensor measures said cardiac wall movements at the first cardiac wall location and emits a first sensor output signal corresponding thereto, a second sensor is positioned at a second cardiac wall location of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the second sensor measures the cardiac wall movements at the second cardiac wall location and emits a second sensor output signal corresponding thereto. A lead arrangement is electrically connected to the first and second sensors and conducts the first and second sensor output signals therefrom to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.

Claims

1. A system for monitoring cardiac synchrony in a human heart, said system comprising:

a first sensor configured for positioning at a first location laterally relative to a cardiac wall of a heart that is subject to movements related to longitudinal valve plane movements of said cardiac wall along the longitudinal axis of the heart, said first sensor being configured to measure said cardiac wall movements at said first location at a first lateral distance from said cardiac wall and to emit a first sensor output signal corresponding thereto;

a second sensor configured for positioning at a second location laterally relative to said cardiac wall of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, said second sensor being configured to measure said movement of said cardiac wall movements at said second location at a second lateral distance from said cardiac wall, that is different from said first lateral distance, and to emit a second sensor output signal corresponding thereto;

a lead arrangement electrically connected to said first and second sensors that conducts said first and second sensor output signals therefrom, respectively; and

processing circuitry connected to said lead arrangement to receive said first and second sensor output signals therefrom, said processing circuitry being configured to process said first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at said first and second cardiac wall locations.

2. A system as claimed in claim 1 wherein said first sensor is configured for placement at a first lateral distance from a ventricular wall, as said first cardiac wall location, and wherein said second sensor is configured for placement at a second lateral distance from the ventricular wall, as said second location.

3. A system as claimed in claim 2 wherein said first sensor is configured for placement at a wall of the right ventricle of the heart and said second sensor is configured for placement at a wall of the left ventricle of the heart, and wherein said processing circuitry is configured to generate an interventricular synchrony signal from said first and second sensor outputs, as said synchronization signal.

4. A system as claimed in claim 2 wherein said first and second sensors are configured for placement at the respective first and second locations of the same ventricle of the heart.

5. A system as claimed in claim 1 wherein at least one of said first and second sensors is configured for placement at an atrial wall, as said first or second location.

6. A system as claimed in claim 1 wherein said first and second sensors are configured for placement at first and second locations that are in proximity to said valve plane, at which said movements of said first and second locations are substantially longitudinal in correspondence with said movements of said valve plane.

7. A system as claimed in claim 1 comprising:

a third sensor carried by said lead arrangement configured for placement at a third location that is subject to said movements related to said longitudinal valve plane movements along the longitudinal axis of the heart, said third sensor measuring said movements of said cardiac wall at said third cardiac wall location and emitting a third sensor output signal corresponding thereto; and

said processing circuitry being configured to also receive and process said third output signal and to produce said synchronization signal from said first, second and third sensor output signals.

8. A system as claimed in claim 7 comprising:

at least one further sensor carried by said lead arrangement and configured for placement at at least one further location that is subject to said movements related to said longitudinal valve plane movements, said at least one further sensor measuring said movements at said at least one further wall location and emitting at least one further sensor output signal corresponding thereto; and

said processing circuitry being configured to also receive and process said at least one further sensor output signal and to produce said synchronization signal from said first, second, third and at least one further sensor output signals.

9. A system as claimed in claim 1 wherein said processing circuitry is configured to discriminate among respective signal contributions from longitudinal and lateral movements in said first and second sensor output signals.

10. A device as claimed in claim 1 wherein said processing circuitry is configured to compare said synchronization signal with a threshold signal and to emit an output indicative of whether cardiac synchrony is present.

11. A system as claimed in claim 1 wherein said processing circuitry is configured to process said first and second output signals by calculating a difference between said first and second output signals and to emit a difference signal, corresponding to said difference, as said synchronization signal.

12. A system as claimed in claim 1 wherein said processing circuitry is configured to process said first and second output signals by cross-correlating respective signal patterns of said first and second sensor output signals to obtain a cross-correlation result, and to emit said cross-correlation result as said synchronization signal.

13. A system as claimed in claim 1 wherein said processing circuitry comprises a neural network configured to process said first and second sensor output signals by neural network signal processing.

14. A system as claimed in claim 1 wherein said first and second sensors are accelerometers.

15. A system as claimed in claim 1 wherein said first and second sensors are piezoelectric pressure sensors.

16. A system as claimed in claim 1 wherein said first and second sensors are configured to measure, at said first and second wall locations, substantially only longitudinal movements.

17. A system as claimed in claim 1 comprising:

a housing configured for implantation in a subject, said housing containing said processing circuitry and having said lead arrangement mechanically and electrically connected thereto;

a pacing pulse generator contained in said housing that emits stimulation pulses for stimulating the heart;

control circuitry connected to said processing circuitry and to said pacing pulse generator and configured to control emission of said stimulation pulses by said pacing pulse generator dependent on said synchronization signal; and

at least one pacing electrode carried by said lead arrangement for delivering said stimulation pulses to cardiac tissue.

18. A system as claimed in claim 17 wherein said control circuitry is configured to change timing parameters associated with delivery of said stimulation pulses in dependence on said synchronization signal.

19. A system as claimed in claim 18 wherein said control circuitry is configured to change said timing parameters when said synchronization signal indicates an absence or reduction of cardiac synchrony.

20. A system as claimed in claim 19 wherein said control circuitry is configured to change said timing parameters to restore cardiac synchrony.

21. A system as claimed in claim 18 wherein said lead arrangement comprises a lead configured for placement in the right ventricle carrying an electrode for delivering some of said stimulation pulses to the right ventricle, and a lead configured for placement in the left ventricle carrying an electrode for delivering some of said stimulation pulses to the left ventricle, and wherein said control circuitry operates said pacing pulse stimulator in a biventricular pacing mode and wherein said timing parameters include a VV interval.

22. A system as claimed in claim 18 wherein said lead arrangement comprises a lead configured for placement in an atrium of the heart that carries an electrode for delivering some of said stimulation pulses to the atrium, and a lead configured for placement in a ventricle of the heart carrying an electrode for delivering some of said stimulation pulses to the ventricle, and wherein said control circuitry is configured to operate said pacing pulse generator in an AV pacing mode, and wherein said timing parameters include an AV interval.

23. A method for monitoring cardiac synchrony in a human heart, comprising the steps of:

positioning a first sensor at a first location laterally relative to a cardiac wall of a heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart and, with said first sensor, measuring said movements at said first location at a first lateral distance from said cardiac wall and emitting a first sensor output signal corresponding thereto;

positioning a second sensor at a second location laterally relative to the cardiac wall of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart and with said second sensor, measuring said movements of said cardiac wall at said second location at a second lateral distance from said cardiac wall, that is different from said first lateral distance, and emitting a second sensor output signal corresponding thereto; and

processing said first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at said first and second locations.

24. A method as claimed in claim 23 comprising placing said first sensor at a first lateral distance from a ventricular wall, as said first location, and placing said second sensor at a second lateral distance from said ventricular wall, as said second location.

25. A method system as claimed in claim 24 comprising placing said first sensor at a wall of the right ventricle of the heart and placing said second sensor at a wall of the left ventricle of the heart, and generating an interventricular synchrony signal from said first and second sensor outputs, as said synchronization signal.

26. A method as claimed in claim 24 comprising placing said first and second sensors at the respective first and second, locations of the same ventricle of the heart.

27. A method system as claimed in claim 23 comprising placing at least one of said first and second sensors at an atrial wall, as said first or second location.

28. A method as claimed in claim 23 comprising placing said first and second sensors at first and second locations that are in proximity to said valve plane, at which said movements of said first and second locations are substantially longitudinal in correspondence with said movements of said valve plane.

29. A method as claimed in claim 23 comprising:

placing a third sensor at a third location that is subject to said movements related to said longitudinal valve plane movements along the longitudinal axis of the heart and, with said third sensor, measuring said cardiac wall movements at said third cardiac wall location and emitting a third sensor output corresponding thereto; and

also processing said third output signal to produce said synchronization signal from said first, second and third sensor output signals.

30. A method as claimed in claim 29 comprising:

placing at least one further sensor at at least one further location that is subject to said movements related to said longitudinal valve plane movements and, with said at least one further sensor, measuring said movements at said at least one further wall location and emitting at least one further sensor output signal corresponding thereto; and

also processing said at least one further sensor output signal to produce said synchronization signal from said first, second, third and at least one further sensor output signals.

31. A method as claimed in claim 23 comprising, in said processing, discriminating among respective signal contributions from longitudinal and lateral movements in said first and second sensor output signals.

32. A method as claimed in claim 23 comprising comparing said synchronization signal with a threshold signal and to emit an output indicative of whether cardiac synchrony is present.

33. A method as claimed in claim 23 comprising processing said first and second output signals by calculating a difference between said first and second output signals and emitting a difference signal, corresponding to said difference, as said synchronization signal.

34. A method as claimed in claim 23 comprising processing said first and second output signals by cross-correlating respective signal patterns of said first and second sensor output signals to obtain a cross-correlation result, and emitting said cross-correlation result as said synchronization signal.

35. A method as claimed in claim 23 comprising processing said first and second sensor output signals by neural network signal processing.

36. A method as claimed in claim 23 comprising measuring, with said first and second sensors, substantially only longitudinal movements at said first and second wall locations.

37. A method as claimed in claim 23 comprising:

emitting stimulation pulses for stimulating the heart; and

controlling emission of said stimulation pulses dependent on said synchronization signal.

38. A method as claimed in claim 37 comprising controlling emission of said stimulation pulses by changing timing parameters associated with delivery of said stimulation pulses in dependence on said synchronization signal.

39. A method as claimed in claim 38 comprising changing said timing parameters when said synchronization signal indicates an absence or reduction of cardiac synchrony.

40. A method as claimed in claim 39 comprising changing said timing parameters to restore cardiac synchrony.

41. A system as claimed in claim 37 comprising delivering some of said stimulation pulses to the right ventricle of the heart, and delivering some of said stimulation pulses to the left ventricle of the heart in a biventricular pacing mode and wherein said timing parameters that are changed include a VV interval.

42. A system as claimed in claim 37 comprising delivering some of said stimulation pulses to an atrium of the heart, and delivering some of said stimulation pulses to a ventricle of the heart in an AV pacing mode, and wherein said timing parameters that are changed include an AV interval.