Apparatus and method for in-vivo plasmapheresis using periodic backflush containing anticoagulant
First Claim
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1. A method for carrying out plasmapheresis, comprising:
- providing a filter device comprising a plurality of elongated hollow microporous fibers;
diffusing plasma and toxins from a patient'"'"'s blood through the wall of the fibers into the hollow interior thereof; and
periodically interrupting the diffusion of plasma and toxins and backflushing the fibers by directing a backflush fluid containing an amount of anticoagulant at least sufficient to provide fiber thromboresistance through a catheter into the fibers at a pressure and for an interval sufficient to substantially clear the pores of the filter, and after the interval, resuming the diffusion of plasma.
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Abstract
Method for in-vivo plasmapheresis utilizing a plurality of elongated hollow microporous filter fibers periodically interrupt diffusion of blood plasma from a patient, and, for a selected time, directing backflush fluid into the fibers at a pressure and interval sufficient to cleanse the fiber pores, after which plasma diffusion is resumed. The backflush fluid, preferably a normal saline solution, may contain an anticoagulant such as heparin, citrate or NO donor in suitable concentration for systemic anti-coagulation or for treating the fiber for thromboresistance.
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Citations
23 Claims
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1. A method for carrying out plasmapheresis, comprising:
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providing a filter device comprising a plurality of elongated hollow microporous fibers; diffusing plasma and toxins from a patient'"'"'s blood through the wall of the fibers into the hollow interior thereof; and periodically interrupting the diffusion of plasma and toxins and backflushing the fibers by directing a backflush fluid containing an amount of anticoagulant at least sufficient to provide fiber thromboresistance through a catheter into the fibers at a pressure and for an interval sufficient to substantially clear the pores of the filter, and after the interval, resuming the diffusion of plasma. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for carrying out plasmapheresis, comprising:
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providing a filter device, the filter device comprising one or more elongated hollow tubes and a plurality of elongated microporous fibers capable of separating plasma from whole blood, each fiber having an interior lumen extending along the length thereof and having a first and second end secured to one or more of the elongated hollow tubes wherein the interior lumen of each of the fibers communicates with the interior of the one or more hollow tubes; providing a catheter in fluid communication with the hollow interior of the fibers, and diffusing plasma and toxins from a patient'"'"'s blood through the wall of the fibers into the hollow interior thereof; and periodically interrupting the diffusion of plasma and toxins and backflushing the fibers by directing a backflush fluid containing an amount of anticoagulant at least sufficient to provide fiber thromboresistance through the catheter into the fibers at a pressure and for an interval sufficient to substantially clear the pores of the filter, and after the interval, resuming the diffusion of plasma. - View Dependent Claims (17, 18, 19)
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20. A method for carrying out plasmapheresis comprising:
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providing a filter device, the filter device comprising one or more elongated hollow tubes and a plurality of elongated microporous fibers having an interior lumen extending along the length thereof, each fiber having a first and second end secured to the one or more elongated hollow tubes, wherein the interior lumen of each of the fibers communicates with the interior of the one or more hollow tubes, and wherein each of the elongated microporous fibers have an asymmetrical fiber wall morphology between the inner wall surface extending along the interior fiber lumen and the outer wall surface, the fiber wall having a higher mass density zone adjacent to the outer wall surface and a lower mass density zone adjacent to the inner wall surface, the higher mass density zone having a smaller average nominal pore size than the average nominal pore size in the lower mass density zone and wherein the fibers are configured to separate plasma from whole blood by passing plasma through the fiber wall from the outer wall surface to the inner wall surface and to the interior lumen thereof; providing a catheter in fluid communication with the hollow interior of the fibers, and diffusing plasma and toxins from a patient'"'"'s blood through the wall of the fibers into the hollow interior thereof; and periodically interrupting the diffusion of plasma and toxins and backflushing the fibers by directing a backflush fluid containing an amount of anticoagulant at least sufficient to provide fiber thromboresistance through the catheter into the fibers at a pressure and for an interval sufficient to substantially clear the pores of the filter, and after the interval, resuming the diffusion of plasma. - View Dependent Claims (21, 22, 23)
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Specification