Medical device with a porous surface for delivery of a therapeutic agent
First Claim
1. An implantable stent comprising:
- a stent sidewall structure comprising(a) a stent strut body having a surface defined by the stent strut body or by a surface coating on the stent strut body, the surface comprising a metal, a metal oxide, a ceramic oxide, or inert carbon;
(b) the surface defining a plurality of cavities therein, at least some of the cavities being in fluid communication with the surface and at least one cavity being defined by a cavity surface having a plurality of pores therein;
(c) a second coating composition comprising a first therapeutic agent, wherein the second coating composition is disposed within a portion of at least one of the cavities; and
(d) a cap disposed in the at least one of the cavities and covering the second coating composition, wherein the cap is within the at least one of the cavities and wherein at least some of the pores in the cavity surface being not covered by the cap and being in fluid communication with the surface,thereby causing the first therapeutic agent to release through the pores to the surface and to not substantially release from the cavity directly to the surface.
1 Assignment
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Accused Products
Abstract
The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.
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Citations
50 Claims
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1. An implantable stent comprising:
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a stent sidewall structure comprising (a) a stent strut body having a surface defined by the stent strut body or by a surface coating on the stent strut body, the surface comprising a metal, a metal oxide, a ceramic oxide, or inert carbon; (b) the surface defining a plurality of cavities therein, at least some of the cavities being in fluid communication with the surface and at least one cavity being defined by a cavity surface having a plurality of pores therein; (c) a second coating composition comprising a first therapeutic agent, wherein the second coating composition is disposed within a portion of at least one of the cavities; and (d) a cap disposed in the at least one of the cavities and covering the second coating composition, wherein the cap is within the at least one of the cavities and wherein at least some of the pores in the cavity surface being not covered by the cap and being in fluid communication with the surface, thereby causing the first therapeutic agent to release through the pores to the surface and to not substantially release from the cavity directly to the surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 50)
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36. A method of coating an implantable stent having a stent sidewall structure, the stent sidewall structure comprising a stent strut body having a surface defined by the stent strut body or by a surface coating on the stent strut body, the surface coating comprising a surface coating composition comprising a metal, a metal oxide or a ceramic oxide, or inert carbon, the stent sidewall structure defining a plurality of pores therein and, the method comprising:
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(a) creating a plurality of cavities in the surface, wherein the cavities have a cavity surface and wherein at least some of the pores are in fluid communication with a portion of the cavity surface; (b) disposing a second composition comprising a first therapeutic agent within a portion of at least one of the cavities; and (c) forming a cap in the at least one of the cavities to cover the second coating composition, wherein the cap is within the at least one of the cavities and wherein at least some of the pores in the cavity surface being not covered by the cap and being in fluid communication with the surface, thereby causing the first therapeutic agent to release through the pores to the surface and to not substantially release from the cavity directly to the surface. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44)
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45. A method of coating an implantable stent having a stent sidewall structure, the stent sidewall structure comprising a strut and a surface coating comprising a surface coating composition comprising a metal, a metal oxide or a ceramic oxide, or inert carbon, the method comprising:
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(a) creating a plurality of cavities in the metal or ceramic oxide or inert carbon, wherein the cavities have a cavity surface; (b) creating a plurality of pores in the metal or ceramic oxide or inert carbon and wherein at least some of the pores are in fluid communication with a portion of the cavity surface; and (c) disposing a second composition comprising a first therapeutic agent within a portion of at least one of the cavities; and (d) forming a cap in the at least one of the cavities to cover the second coating composition, wherein the cap is within the at least one of the cavities and wherein at least some of the pores in the cavity surface being not covered by the cap and being in fluid communication with the surface, thereby causing the first therapeutic agent to release through the pores to the surface and to not substantially release from the cavity directly to the surface. - View Dependent Claims (46, 47, 48, 49)
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Specification