Dispersions of microemulsions in hydrogels for drug delivery

• US 8,071,121 B2
• Filed: 09/04/2007
• Issued: 12/06/2011
• Est. Priority Date: 06/05/2002
• Status: Active Grant

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Chauhan, Anuj, Kapoor, Yash, Gulsen Onbilger, Derya, Li, Chi-Chung
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US11/896,571
• Publication Number:
  US 20080075757A1
• Time in Patent Office: 1,554 Days
• Field of Search: None
• US Class Current: 424/429
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 31/41 having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61K 9/5115 Inorganic compounds
• CPC Class Codes: A61K 9/5138 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/5192 Processes
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein as an oil-in-water microemulsion, an ophthalmically bioactive agent encapsulated in the oil phase, the oil phase comprising a material from which the agent VAN diffuse into and migrate through the contact lens into the post-lens tear film when the contact lens is placed on the eye and wherein the microemulsion is stabilized by the presence of a surfactant with sufficient packing at the oil-water interface to attenuate the rate of diffusion into and migration of agent through the contact lens.

Claims

1. An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein as an oil-in-water microemulsion, an ophthalmically bioactive agent encapsulated in the oil phase of the microemulsion, the oil phase comprising an ophthalmically acceptable material from which the agent is capable of diffusion into and migration through the contact lens and into the post-lens tear film when the contact lens is placed on the eye and wherein the microemulsion is stabilized by the presence of an ophthalmically acceptable surfactant with sufficient packing at the oil-water interface to attenuate the rate of diffusion into and migration of agent through the contact lens.

2. A bioactive agent delivery system of claim 1 wherein said contact lens comprises a polymer of at least one hydrophilic monomer.

3. A bioactive agent delivery system of claim 1 wherein said contact lens comprises a hydrophobic material.

4. A bioactive agent delivery system of claim 3 wherein said hydrophilic monomer is a methacrylic or acrylic acid, 2-hydroxyethylmethacrylate, 2-hydroxyethylacrylate, N-vinyl pyrrolidone, methacrylamide or N,N-dimethylacrylamide.

5. A bioactive agent delivery system of claim 4 wherein said hydrophilic monomer is an unsaturated carboxylic acid;

acrylic substituted alcohol;

vinyl lactam or acrylamide.

6. A bioactive agent delivery system of claim 3 wherein said hydrophobic material is selected from the group consisting of a silicone, silicone containing prepolymers and macromers, polydimethylsiloxane, pentamethyldisiloxanyl methylmethacrylate, tris(trimethylsiloxy)methacryloxy;

propylsilane, methyldi(trimethylsiloxy)methacryloxymethyl silane, monomethacryloxypropyl terminated mono-n-butyl terminated polydimethylsiloxane, mono-(3-methacryloxy-2-hydroxypropyloxy)propyl terminated, mono-butyl terminated polydimethylsiloxane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxanes, 3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, and methyl methacrylate, ethylene glycol di-methacrylate, and mixtures thereof.