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Intrabuccally rapidly disintegrating tablet and a production method of the tablets

  • US 8,071,128 B2
  • Filed: 06/20/2003
  • Issued: 12/06/2011
  • Est. Priority Date: 06/14/1996
  • Status: Expired due to Fees
First Claim
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1. A method of producing an intrabuccally rapidly disintegrating tablet, said intrabuccally rapidly disintegrating tablet comprising:

  • a sugar alcohol or saccharide in the form of primary particles having an average particle size of not more than 30 μ

    m;

    an active ingredient; and

    one or more disintegrants selected from the group consisting of crospovidone, croscarmellose sodium, low substituted hydroxypropylcellulose, and a mixture thereof,said method comprising the steps of;

    (a) granulating a powder material comprising the sugar alcohol or saccharide and said one or more disintegrants, thereby producing granulated material having a predetermined size;

    (b) mixing said granulated material and said active ingredient; and

    (c) compressing the mixture into an intrabuccally rapidly disintegrating tablet.

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