Intrabuccally rapidly disintegrating tablet and a production method of the tablets
First Claim
1. A method of producing an intrabuccally rapidly disintegrating tablet, said intrabuccally rapidly disintegrating tablet comprising:
- a sugar alcohol or saccharide in the form of primary particles having an average particle size of not more than 30 μ
m;
an active ingredient; and
one or more disintegrants selected from the group consisting of crospovidone, croscarmellose sodium, low substituted hydroxypropylcellulose, and a mixture thereof,said method comprising the steps of;
(a) granulating a powder material comprising the sugar alcohol or saccharide and said one or more disintegrants, thereby producing granulated material having a predetermined size;
(b) mixing said granulated material and said active ingredient; and
(c) compressing the mixture into an intrabuccally rapidly disintegrating tablet.
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Accused Products
Abstract
An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
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Citations
15 Claims
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1. A method of producing an intrabuccally rapidly disintegrating tablet, said intrabuccally rapidly disintegrating tablet comprising:
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a sugar alcohol or saccharide in the form of primary particles having an average particle size of not more than 30 μ
m;an active ingredient; and one or more disintegrants selected from the group consisting of crospovidone, croscarmellose sodium, low substituted hydroxypropylcellulose, and a mixture thereof, said method comprising the steps of; (a) granulating a powder material comprising the sugar alcohol or saccharide and said one or more disintegrants, thereby producing granulated material having a predetermined size; (b) mixing said granulated material and said active ingredient; and (c) compressing the mixture into an intrabuccally rapidly disintegrating tablet. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification