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Thyroid hormone analogs and methods of use

  • US 8,071,134 B2
  • Filed: 09/15/2005
  • Issued: 12/06/2011
  • Est. Priority Date: 09/15/2003
  • Status: Active Grant
First Claim
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1. A method for treating a condition amenable to treatment by inhibiting angiogenesis, said method comprising administering to a subject in need thereof an amount of an anti-angiogenesis agent effective for inhibiting angiogenesis in said subject, wherein said condition amenable to treatment by inhibiting angiogenesis is glioma, wherein said anti-angiogenesis agent is tetraiodothyroacetic acid (TETRAC), triiodothyroacetic acid (TRIAC), or combinations thereof, and wherein the agent effective for inhibiting angiogenesis acts at the cell surface and is conjugated via a covalent bond to a polymer selected from the group consisting of polyglycolide, polylactide, and co-polymers thereof.

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