Endoprostheses

• US 8,071,156 B2
• Filed: 03/04/2009
• Issued: 12/06/2011
• Est. Priority Date: 03/04/2009
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Weber, Jan, Scheuermann, Torsten
• Primary Examiner(s): Barr, Michael
• Assistant Examiner(s): BOWMAN, ANDREW J
• Application Number:
  US12/397,509
• Publication Number:
  US 20100228341A1
• Time in Patent Office: 1,007 Days
• Field of Search: 427/180, 427/162, 424/422, 623/1.46, 657/11
• US Class Current: 427/2.24
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 33/00 Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment

Abstract

A hydrophilic ceramic coating is formed on an endoprosthesis preform. The hydrophilic ceramic coating is porous and can store nano-sized drug particles.

Claims

1. A method of making an endoprosthesis, comprising:

(a) depositing a sol gel solution including a titanium dioxide precursor and a polymer to form a ceramic coating on a preform, the polymer comprising polyethylene glycol having a molecular weight larger than 6000, and the titanium oxide precursor comprising titanium alkoxide; and

(b) treating the ceramic coating with a UV light.

2. The method of claim 1, wherein the ceramic coating formed in step (a) is hydrophobic and has a contact angle greater than 90°

, and during step (b), at least a portion of the ceramic coating is made less hydrophobic.

3. The method of claim 1, comprising depositing the sol gel solution by spin coating.

4. The method of claim 1, wherein the ceramic coating comprises pores and step (a) further comprises forming the pores by decomposing polyethylene glycol.

5. The method of claim 4, comprising decomposing polyethylene glycol by calcination.

6. The method of claim 1, further comprising exposing the ceramic coating to water vapor before step (b).

7. The method of claim 1, wherein the ceramic coating includes pores and step (b) further comprises loading a therapeutic agent into the pores.

8. The method of claim 7, comprising loading the therapeutic agent by dipping the preform in an aqueous solution containing albumin paclitaxcel nanoparticles.

9. The method of claim 1, wherein after step (b), the ceramic coating is hydrophilic and has a contact angle of at most 30 degrees.

10. The method of claim 1, wherein the ceramic coating comprises silicon dioxide.

11. The method of claim 10, wherein the ceramic coating comprises 0-50 mol % of silicon dioxide.

12. The method of claim 10, wherein step (a) further comprises separating phases of the silicon dioxide and titanium dioxide in the ceramic coating to form pores in the ceramic coating.

13. The method of claim 6, wherein the water vapor has a temperature of about 60°

C. to about 180°

C.

14. The method of claim 7, wherein the therapeutic agent is in the form of nanoparticles.