Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
First Claim
1. A method for reducing the expression of the atrial natriuretic peptide receptor A (NPRA) in a mammalian subject having lung cancer or melanoma, comprising administering an interfering RNA molecule or antisense molecule to the subject, wherein the interfering RNA molecule or antisense molecule is targeted to a nucleic acid sequence within the NPRA gene or transcript, and wherein the interfering RNA molecule or antisense molecule is administered in an effective amount to reduce NPRA expression, and lung cancer cell growth or melanoma cell growth, in the subject.
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Abstract
This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the inflammation associated with many human diseases, such as asthma, respiratory syncytial virus (RSV) infection, and cancers (such as melanoma, lung cancer, and/or ovarian cancer) by interfering with NPRA gene expression or otherwise reducing NPRA function within a subject; and methods for treating a subject suffering from, or at risk of developing, an inflammatory disease, respiratory allergy (such as allergic rhinitis and asthma), viral infection, and/or cancer by administering such NPRA inhibitors to the subject.
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16 Claims
- 1. A method for reducing the expression of the atrial natriuretic peptide receptor A (NPRA) in a mammalian subject having lung cancer or melanoma, comprising administering an interfering RNA molecule or antisense molecule to the subject, wherein the interfering RNA molecule or antisense molecule is targeted to a nucleic acid sequence within the NPRA gene or transcript, and wherein the interfering RNA molecule or antisense molecule is administered in an effective amount to reduce NPRA expression, and lung cancer cell growth or melanoma cell growth, in the subject.
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