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Stable recombinant adenosine deaminase

  • US 8,071,741 B2
  • Filed: 04/18/2008
  • Issued: 12/06/2011
  • Est. Priority Date: 04/20/2007
  • Status: Active Grant
First Claim
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1. An isolated recombinant adenosine deaminase comprising the polypeptide of SEQ ID NO:

  • 1, or an isolated recombinant adenosine deaminase variant polypeptide of SEQ ID NO;

    1, wherein the polypeptide variant of SEQ ID NO;

    1 comprises one or more amino acid substitutions selected from the group consisting of;

    Gin in place of Lys198;

    Ala in place of Thr245; and

    Arg in place of Gly351.

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