Stable recombinant adenosine deaminase
First Claim
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1. An isolated recombinant adenosine deaminase comprising the polypeptide of SEQ ID NO:
- 1, or an isolated recombinant adenosine deaminase variant polypeptide of SEQ ID NO;
1, wherein the polypeptide variant of SEQ ID NO;
1 comprises one or more amino acid substitutions selected from the group consisting of;
Gin in place of Lys198;
Ala in place of Thr245; and
Arg in place of Gly351.
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Abstract
A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized recombinant adenosine deaminase, polymer conjugates and methods of treatment using the same are also disclosed.
48 Citations
19 Claims
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1. An isolated recombinant adenosine deaminase comprising the polypeptide of SEQ ID NO:
- 1, or an isolated recombinant adenosine deaminase variant polypeptide of SEQ ID NO;
1, wherein the polypeptide variant of SEQ ID NO;
1 comprises one or more amino acid substitutions selected from the group consisting of;
Gin in place of Lys198;
Ala in place of Thr245; and
Arg in place of Gly351. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19)
- 1, or an isolated recombinant adenosine deaminase variant polypeptide of SEQ ID NO;
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17. An isolated DNA that encodes a recombinant adenosine deaminase having the amino acid sequence comprising SEQ ID NO:
- 1.
Specification