Fiber-optic localized plasmon resonance sensing device and system thereof

• US 8,072,606 B2
• Filed: 07/20/2009
• Issued: 12/06/2011
• Est. Priority Date: 01/20/2009
• Status: Active Grant

• Current Assignee: National Chung Cheng University
• Original Assignee: National Chung Cheng University
• Inventors: Chau, Lai-Kwan, Yang, Chung-Shi, Chang, Wei-Zhe, Wu, Wei-Te
• Primary Examiner(s): Ton, Tri T
• Application Number:
  US12/505,975
• Publication Number:
  US 20100182607A1
• Time in Patent Office: 869 Days
• Field of Search: 356445-448, 356300-301, 436501-503, 422/68.1, 422/50, 702/19, 702/1, 250/458.1
• US Class Current: 356/445
• CPC Class Codes: G01N 2021/7716 in cladding
• CPC Class Codes: G01N 2021/773 Porous polymer jacket; Polymer matrix with indicator
• CPC Class Codes: G01N 21/554 detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
• CPC Class Codes: G01N 21/648 using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
• CPC Class Codes: G01N 21/658 enhancement Raman, e.g. surface plasmons
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G02B 6/0229 characterised by nanostructures, i.e. structures of size less than 100 nm, e.g. quantum dots

Abstract

The present invention discloses a fiber-optic localized plasmon resonance (FO-LPR) sensing device and a sensing system thereof, the FO-LPR sensing system includes a light source, a FO-LPR sensing device and a detector, and the light source provides a light beam entered into the FO-LPR sensing device, and the detector generates a detected signal according to an emergent light from the FO-LPR sensing device. The FO-LPR sensing device includes an optical fiber, a noble metal nanoparticle layer and a filter film layer. The filter film layer is having a porous material, and the porous material comes with a pore diameter or a property selected according to a feature of a sample, while an interfering substance in the sample is isolated.

Claims

1. A fiber-optic localized plasmon resonance (FO-LPR) sensing device, comprising:

at least one optical fiber;

a noble metal nanoparticle layer, disposed on the optical fiber; and

a filter film layer, having a porous material, and encloses the optical fiber;

wherein the porous material comes with a pore diameter or a property selected according to a feature of a sample while an interfering substance in the sample is isolated.

2. The FO-LPR sensing device of claim 1, wherein the optical fiber has a region with an entire cladding removed, or the optical fiber has a region with a portion of the cladding removed, and the cladding removed area of the optical fiber is a sensing area.

3. The FO-LPR sensing device of claim 1, wherein the noble metal nanoparticle layer interacts with an incident light to produce a fluorescent light or a surface-enhanced Raman scattering light.

4. The FO-LPR sensing device of claim 1, wherein the filter film layer comes with the pore diameter from 0.2 μ

m to 20 μ

m, a pore density from 4×

10⁴ cm<sup>−

2</sup> to 20×

10⁴ cm<sup>−

2</sup>,a thickness from 50 μ

m to 100 μ

m or a molecular weight cut off (MWCO) smaller than or equal to 500 kDa.

5. The FO-LPR sensing device of claim 1, further comprising a rigid frame with an opening on its wall and disposed between the filter film layer and the optical fiber, for providing a physical support and guiding the sample to a specific sensing area.

6. The FO-LPR sensing device of claim 1, further comprising at least one duct disposed inside a region enclosed by the filter film layer for introducing a perfusion liquid or discharging the perfusion liquid.

7. The FO-LPR sensing device of claim 1, wherein the optical fiber includes a mirror coating coated at an end of the optical fiber for reflecting a light signal.

8. The FO-LPR sensing device of claim 1, wherein the noble metal nanoparticle layer is disposed onto an end of the optical fiber for scattering or reflecting a light signal.

9. The FO-LPR sensing device of claim 1, wherein the optical fiber forms a hollow cavity at an end of the optical fiber by etching a portion of a core, and the hollow cavity is filled by the porous material for disposing noble metal nanoparticles on the surface of the porous material.

10. A fiber-optic localized plasmon resonance (FO-LPR) sensing system, comprising:

a FO-LPR sensing device, comprising;

at least one optical fiber;

a noble metal nanoparticle layer, disposed on the optical fiber; and

a filter film layer, having a porous material, and encloses the optical fiber;

a light source, for providing a light beam entered into the FO-LPR sensing device; and

a detector, for receiving an emergent light from the FO-LPR sensing device to generate a detected signal;

wherein the porous material comes with a pore diameter or a property selected according to a feature of a sample, while an interfering substance in the sample is isolated.

11. The FO-LPR sensing system of claim 10, wherein the optical fiber has a region with an entire cladding removed, or the optical fiber has a region with a portion of the cladding removed, and the cladding removed area of the optical fiber is a sensing area.

12. The FO-LPR sensing system of claim 10, wherein the noble metal nanoparticle layer interacts with an incident light to produce a fluorescent light or a surface-enhanced Raman scattering light.

13. The FO-LPR sensing system of claim 10, wherein the filter film layer comes with the pore diameter from 0.2 μ

m to 20 μ

m, a pore density from 4×

10⁴ cm<sup>−

2</sup> to 20×

10⁴ cm<sup>−

2</sup>, a thickness from 50 μ

m to 100 μ

m or a molecular weight cut off (MWCO) smaller than or equal to 500 kDa.

14. The FO-LPR sensing system of claim 10, further comprising a rigid frame with an opening on its wall and disposed between the filter film layer and the optical fiber, for providing a physical support and introducing the sample to a specific sensing area.

15. The FO-LPR sensing system of claim 10, wherein the optical fiber includes a mirror coating coated at an end of the optical fiber for reflecting a light signal.

16. The FO-LPR sensing system of claim 10, wherein the noble metal nanoparticle layer is disposed onto an end of the optical fiber for scattering or reflecting a light signal.

17. The FO-LPR sensing system of claim 10, wherein the optical fiber forms a hollow cavity at an end of the optical fiber by etching a portion of a core, and the hollow cavity is filled by the porous material for disposing noble metal nanoparticles onto the surface of the porous material.

18. The FO-LPR sensing system of claim 10, wherein the light source is a laser or a light emitting diode (LED).

19. The FO-LPR sensing system of claim 10, wherein the detector is a photodiode, a phototransistor, a photomultiplier (PMT) or a charge coupling device (CCD).

20. The FO-LPR sensing system of claim 10, further comprising at least one duct or a pump, and the duct is disposed inside a region enclosed by the filter film layer for introducing a perfusion liquid or discharging the perfusion liquid, and the pump draws the perfusion liquid through the duct into a region enclosed by the filter film layer or removes the perfusion liquid through the duct from a region enclosed by the filter film layer.