Neurostimulator involving stimulation strategies and process for using it

• US 8,073,544 B2
• Filed: 05/31/2005
• Issued: 12/06/2011
• Est. Priority Date: 04/05/2000
• Status: Expired due to Term

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuropace Inc.
• Inventors: Pless, Benjamin D.
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): Lavert, Nicole F
• Application Number:
  US11/142,063
• Publication Number:
  US 20050222641A1
• Time in Patent Office: 2,380 Days
• Field of Search: 607/45, 607/62, 607/72, 600/544
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters

Abstract

This is a neurostimulator that is configured to treat epilepsy and other neurological disorders using certain stimulation strategies, particularly changing various pulse parameters, during the imposition of a burst of those pulses. The invention includes the processes embodying those stimulation strategies.

Claims

1. A method for treating an abnormal neurological condition comprising:

defining a plurality of bursts of electrical stimulation to treat the abnormal neurological condition, each burst of the plurality of bursts comprises a determined number of electrical pulses, the plurality of bursts and the determined number of electrical pulses being characterizable by a plurality of burst parameters;

applying the plurality of bursts of electrical stimulation to brain tissue;

varying at least one of the burst parameters during at least a portion of the time the plurality of bursts of electrical stimulation is applied to vary the bursts so that the burst parameters of at least one burst of the plurality of bursts are different from the burst parameters of at least one other burst; and

detecting electrical activity of the brain tissue, wherein the detected electrical activity is characterized by at least one detected parameter; and

selecting the at least one burst parameter to vary based on the at least one detected parameter.

2. The method of claim 1 wherein the burst parameters include the interval between the pulses within the at least one burst, the amplitude of the individual pulses within the plurality of bursts, the width of the individual pulses within the plurality of bursts, and the presence or absence of a hyperpolarizing pre-pulse at the start of the plurality of bursts.

3. The method of claim 1 wherein one of the burst parameters varied during at least a portion of the time the plurality of bursts of stimulation are applied is varied randomly, pseudo-randomly, or in a fractal manner.

4. The method of claim 1 wherein one of the burst parameters is the amplitude of the individual pulses within the plurality of bursts, and the amplitude is varied systematically so that the amplitude increases or decrease from the beginning to the end of the burst.

5. The method of claim 1 wherein a plurality of bursts of electrical stimulation are defined, a plurality of bursts of electrical stimulation are applied to the brain tissue, one of the burst parameters is the existence or absence of a hyperpolarizing pre-pulse at the start of the plurality of bursts, and the existence or absence of a hyperpolarizing pre-pulse is varied so that sometimes it is included in a burst when the burst is applied and sometimes it is not included in a burst when the burst is applied.