Method of electrogenically controlling pump molecules
First Claim
1. A method of controlling the cycle of a plurality of carrier-mediated ion transporters comprising the steps of:
- applying an oscillating electric field at a predetermined synchronization frequency wherein the frequency is substantially equal to the ion transporters initial natural turnover rate; and
incrementally adjusting the synchronization frequency to control the cycle.
3 Assignments
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Accused Products
Abstract
Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example in a physiological operating mode by applying the concept of an electronic synchrotron to the biological system. It was shown that individual Na/K pump molecules can be synchronized by a well designed oscillating electric field. The synchronized pump currents show separated inward and outward pump currents and a magnitude ratio of 3:2 reflecting stoichiometric number of the pump molecules.
11 Citations
18 Claims
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1. A method of controlling the cycle of a plurality of carrier-mediated ion transporters comprising the steps of:
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applying an oscillating electric field at a predetermined synchronization frequency wherein the frequency is substantially equal to the ion transporters initial natural turnover rate; and incrementally adjusting the synchronization frequency to control the cycle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of controlling the cycle of a plurality of Na/K pump molecules comprising the steps of:
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applying an oscillating electric field at a predetermined synchronization frequency wherein the frequency is substantially equal to the pump molecules'"'"' initial natural turnover rate and; incrementally adjusting the synchronization frequency to control the cycle. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification