Biopolymer array reading

• US 8,073,626 B2
• Filed: 01/31/2003
• Issued: 12/06/2011
• Est. Priority Date: 01/31/2003
• Status: Active Grant

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Troup, Charles D., Cattell, Herbert F.
• Primary Examiner(s): Dejong, Eric S
• Application Number:
  US10/355,571
• Publication Number:
  US 20040152082A1
• Time in Patent Office: 3,231 Days
• Field of Search: None
• US Class Current: 702/19
• CPC Class Codes: B01J 2219/00549 2-dimensional
• CPC Class Codes: B01J 2219/00565 Electromagnetic means
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00668 Two-dimensional arrays within three-dimensional arrays
• CPC Class Codes: B01J 2219/00702 Processes involving means for analysing and characterising the products
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01J 2219/00725 Peptides
• CPC Class Codes: C40B 40/06 Libraries containing nucleotides or polynucleotides, or derivatives thereof
• CPC Class Codes: C40B 40/10 Libraries containing peptides or polypeptides, or derivatives thereof
• CPC Class Codes: C40B 70/00 Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
• CPC Class Codes: G16B 25/00 ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

Abstract

A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.

Claims

1. A method of processing biopolymer arrays, comprising:

(a) reading a different array identifier for each biopolymer array from a tag associated with that array;

(b) reading at least some of the biopolymer arrays and saving results from each read biopolymer array in a memory linked with the read identifier for that array;

(c) receiving different communication addresses and a selection of an array identifier for each communication address;

(d) for at least some of the read biopolymer arrays of step (b), matching the saved results for each array with one of the different communication addresses using the identifier, and transmitting the saved results for those arrays to the matched different communication addresses.

2. The method according to claim 1 wherein the biopolymer arrays are polynucleotide arrays.

3. The method according to claim 2 additionally comprising for at least some of the selection of array identifiers received in (c), transmitting status information on array reading to the communication address for each.

4. The method according to claim 2 wherein for at least some of the arrays, (c) occurs before (b) and the method additionally comprises:

saving the different communication addresses and the selected array identifier for each in a memory;

following reading and saving of results and read array identifiers in (b), then automatically performing the matching and transmitting of (d).

5. The method according to claim 2 wherein for at least some of the arrays (b) occurs before (c) and the method additionally comprises:

following the receiving in (c), then automatically performing the matching and transmitting of (d).

6. The method according to claim 2 wherein the tag for each array is associated with the array by being carried by a substrate on which the array is located.

7. The method according to claim 2 wherein the tag for each array is associated with the array by being on or in a same package as the array.

8. The method according to claim 2 wherein the tag comprises a bar code.

9. The method according to claim 2 wherein the tag comprises an electrically readable memory.

10. The method according to claim 1 wherein the arrays are peptide arrays.

11. An array reading station for reading multiple biopolymer arrays comprising:

(a) an identifier reader to read a different array identifier for each biopolymer array from a tag associated with that array;

(b) an array reader to read arrays, which array reader may be the same or different from the identifier reader;

(c) a memory unit;

(d) a communications unit to receive and transmit data; and

(e) a processing unit in communication with the identifier reader, array reader, and memory, and which executes the method of claim 1.

12. The array reading station according to claim 11, wherein the communications unit receives different communication addresses and a selection of an array identifier for each communication address, and wherein, for at least some of the selection of array identifiers received, the communication unit transmits status information on array reading to the communication address for each array identifier.

13. The array reading station according to claim 12 wherein for at least some of the arrays, the receiving occurs before the transmitting and:

the different communication addresses and the selected array identifier for each are saved in the memory unit; and

following reading and saving of results and read array identifiers, then the processor unit automatically performs the matching and transmitting.

14. The array reading station according to claim 12 wherein for at least some of the arrays the reading and saving of results occurs before the receiving and, following the receiving, the processor automatically performs the matching and transmitting.

15. A computer program product comprising a computer readable medium carrying a computer program code which performs the method of claim 2.

16. The computer program product according to claim 15 additionally comprising for at least some of the received selection of array identifiers, transmitting status information on array reading to the communication address for each.

17. The computer program product according to claim 15 wherein for at least some of the arrays (b) occurs before (c) and the method additionally comprises:

following the receiving in (c), then automatically performing the matching and communicating of (d).

18. The computer program product according to claim 15, wherein the tag for each array is associated with the array by being carried by a substrate on which the array is located.

19. The computer program product according to claim 15, wherein the tag for each array is associated with the array by being on or in a same package as the array.

20. A method comprising transmitting a communication address and a selection of an array identifier for each, and receiving as a result of the method of claim 2 the results from reading the array specified by that array identifier.

22. The method according to claim 1, wherein said biopolymer arrays are addressable.

23. The method according to claim 1, wherein said reading of said biopolymer arrays comprises scanning an illumination source across said biopolymer arrays and detecting a fluorescent signal.

24. The method according to claim 1, wherein said communication address is for a local user station.

25. The method according to claim 1, wherein said communication address is for a remote user station.

21. A method of processing data from the reading of biopolymer arrays, comprising:

(a) receiving results from reading each array with a linked read array identifier, and saving each read array result in a memory linked to the array identifier;

(b) receiving different communications addresses and a selection of an array identifier for each communication address;

(c) for at least some of the arrays, matching the saved results for each array with one of the different communication addresses using the identifier, and transmitting the saved results for those arrays to the matched different communication addresses.