Simulation system of function of biological organ
First Claim
1. A simulation system for simulating a function of a biological organ associated with diabetes, the simulation system comprising:
- a computer readable storage medium having stored therein instructions executable by a processor for performing the steps of;
storing a mathematical model that comprises a plurality of parameters and represents a function of a biological organ associated with diabetes;
receiving input of time-series actual measurement data representing blood glucose and/or blood insulin levels obtained by measuring the biological response of a subject;
estimating data representing blood glucose and/or blood insulin levels of the subject at a time point that is different from the time-series actual measurement data,generating time-series reference data representing the biological response of the subject based on the time-series actual measurement data and the estimated data;
acquiring a plurality of sets of parameter values of the mathematical model;
comparing each virtual biological response generated when each of the plurality of sets of parameter values is applied to the mathematical model with the generated time-series reference data; and
selecting one of the plurality of sets of parameter values based on the comparison so as to generate a plurality of parameter values wherein the mathematical model for the subject represents the function of the biological organ when the plurality of parameter values are applied to the model.
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Abstract
A simulation system for simulating a function of a biological organ using a biological model in which the function of the biological organ are represented by a mathematical model with a computer is provided. The present system receives input of time-series actual measurement data representing the biological response of a subject, estimates the biological response of the subject at a time point at which the measurement is not performed by using the input time-series actual measurement data, and generates time-series reference data representing the biological response of the subject. The present system further generates a virtual biological organ virtually constructed in a computer system using the times-series reference data. The virtual biological organ corresponds to the function of a biological organ of the subject.
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Citations
9 Claims
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1. A simulation system for simulating a function of a biological organ associated with diabetes, the simulation system comprising:
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a computer readable storage medium having stored therein instructions executable by a processor for performing the steps of; storing a mathematical model that comprises a plurality of parameters and represents a function of a biological organ associated with diabetes; receiving input of time-series actual measurement data representing blood glucose and/or blood insulin levels obtained by measuring the biological response of a subject; estimating data representing blood glucose and/or blood insulin levels of the subject at a time point that is different from the time-series actual measurement data, generating time-series reference data representing the biological response of the subject based on the time-series actual measurement data and the estimated data; acquiring a plurality of sets of parameter values of the mathematical model; comparing each virtual biological response generated when each of the plurality of sets of parameter values is applied to the mathematical model with the generated time-series reference data; and selecting one of the plurality of sets of parameter values based on the comparison so as to generate a plurality of parameter values wherein the mathematical model for the subject represents the function of the biological organ when the plurality of parameter values are applied to the model. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification