System for treating ocular disorders and methods thereof

• US 8,075,511 B2
• Filed: 04/28/2008
• Issued: 12/13/2011
• Est. Priority Date: 04/07/2001
• Status: Expired due to Term

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Tu, Hosheng, Smedley, Gregory T., Haffner, David, Niksch, Barbara A.
• Primary Examiner(s): Kidwell, Michele M
• Assistant Examiner(s): Treyger, Ilya Y
• Application Number:
  US12/111,033
• Publication Number:
  US 20080200860A1
• Time in Patent Office: 1,324 Days
• Field of Search: 604 7- 10, 604/264, 604/117, 604/289, 604/290, 604/521, 604/48, 604/131, 604/294, 604/298, 604/107, 604/108, 604 27- 31, 604/35, 604/503, 604/505, 604/22, 606/107, 606/108, 606/109, 606/167, 606/170
• US Class Current: 604/8
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 27/00 Drainage appliance for wounds or the like , i.e. wound drains, implanted drains negative pressure wound therapy devices A61M1/90; implements for holding wound open A61B17/02 ; middle ear drainage A61F11/202

Abstract

Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.

Claims

1. A system for treating an ocular disorder, comprising:

an implant having an inlet portion and an outlet portion, a lumen extending between the inlet portion and the outlet portion and communicating with inlet and outlet ports, the implant sized so that in use aqueous humor flows from an anterior chamber of an eye into the lumen through the inlet port and then through the outlet port and into a uveal scleral outflow path of the eye; and

a delivery device configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet port communicates with the uveal scleral outflow path and the inlet port communicates with the anterior chamber, the delivery device being configured to access the anterior chamber through a corneal incision having a size less than about 1 mm;

wherein the delivery device comprises a handpiece and an elongate tip connected to a distal end of the handpiece, wherein the elongate tip comprises a distal portion configured to hold the implant, and wherein the distal portion of the elongate tip has a deflection range.

2. The system of claim 1, wherein the implant is sized so that in use it contacts a choroid of the eye.

3. The system of claim 1, wherein the outlet portion has a head portion, and wherein the outlet port is located along a surface of the head portion.

4. The system of claim 3, wherein said surface is generally curvilinear.

5. The system of claim 3, wherein the head portion has a bulbous shape.

6. The system of claim 1, wherein the inlet portion comprises a seat to stabilize the implant within the eye.

7. The system of claim 1, wherein a shank extends between said inlet portion and said outlet portion.

8. The system of claim 1, wherein the implant further comprises a cutting member.

9. The system of claim 8, wherein the cutting member has a cutting tip configured to make an incision in eye tissue for receiving at least a portion of the implant.

10. The system of claim 1, wherein the implant further comprises at least one anchor to anchor the implant within the eye.

11. The system of claim 1, wherein the implant further comprises a flow controller to regulate the flow of aqueous humor through the implant.

12. The system of claim 11, wherein the flow controller comprises a valve.

13. The system of claim 11, wherein the flow controller comprises a constriction within the lumen of the implant.

14. The system of claim 1, wherein the implant comprises a therapeutic agent.

15. The system of claim 1, wherein the delivery device comprises a distal portion configured to hold the implant, and wherein the distal portion is non-linear and is configured to position the implant at said location in the eye.

16. The system of claim 15, wherein the distal portion of the delivery device is configured to extend within the anterior chamber and is angled to position the implant at said location in the eye.

17. The system of claim 1, wherein the delivery device comprises a proximal portion and a distal portion configured to hold the implant, and wherein the proximal portion is movably attached to the distal portion.

18. The system of claim 17, wherein the proximal portion is attached to the distal portion at a movable joint.

19. The system of claim 1, wherein the delivery device comprises a proximal portion and a distal portion configured to hold the implant, and wherein an angle formed between the proximal portion and the distal portion can change.

20. The system of claim 1, wherein the delivery device further comprises a holder attached to the distal portion of the elongate tip, and wherein the holder is configured to hold and release at least part of the implant.

21. The system of claim 20, wherein the delivery device further comprises an actuator on the handpiece, and wherein the actuator is configured to actuate the holder to release the implant from the holder.

22. The system of claim 1, wherein the distal portion of the elongate tip is made of a flexible material.

23. The system of claim 1, wherein the implant comprises a body made of a flexible material.

24. The system of claim 1, wherein the delivery device has a curved configuration so as to position the implant at said location with the outlet port communicating with the uveal scleral outflow path.

25. The system of claim 1, wherein the delivery device has a bent configuration so as to position the implant at said location with the outlet port communicating with the uveal scleral outflow path.

26. The system of claim 1, wherein the corneal incision is self sealing.

27. The system of claim 1, wherein at least a portion of the implant comprises hydrogel.

28. The system of claim 1, wherein the implant is expandable upon implantation.

29. A system for treating an ocular disorder, comprising:

an implant having an inlet portion and an outlet portion, a lumen extending between the inlet portion and the outlet portion and communicating with inlet and outlet ports, the implant sized so that in use aqueous humor flows from an anterior chamber of an eye into the lumen through the inlet port and then through the outlet port and into a uveal scleral outflow path of the eye; and

a delivery device configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet port communicates with the uveal scleral outflow path and the inlet port communicates with the anterior chamber, the delivery device being configured to access the anterior chamber through a corneal incision having a size less than about 1 mm;

wherein the delivery device comprises a proximal portion and a distal portion configured to hold the implant, and wherein the proximal portion is movably attached to the distal portion.

30. The system of claim 29, wherein the proximal portion is attached to the distal portion at a movable joint.

31. The system of claim 29, wherein the implant is sized so that in use it contacts a choroid of the eye.

32. The system of claim 29, wherein the implant further comprises a cutting member.

33. The system of claim 29, wherein the implant further comprises at least one anchor to anchor the implant within the eye.

34. A system for treating an ocular disorder, comprising:

an implant having an inlet portion and an outlet portion, a lumen extending between the inlet portion and the outlet portion and communicating with inlet and outlet ports, the implant sized so that in use aqueous humor flows from an anterior chamber of an eye into the lumen through the inlet port and then through the outlet port and into a uveal scleral outflow path of the eye; and

a delivery device configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet port communicates with the uveal scleral outflow path and the inlet port communicates with the anterior chamber, the delivery device being configured to access the anterior chamber through a corneal incision having a size less than about 1 mm;

wherein the delivery device comprises a proximal portion and a distal portion configured to hold the implant, and wherein an angle formed between the proximal portion and the distal portion can change.

35. The system of claim 34, wherein the implant comprises a therapeutic agent.

36. The system of claim 34, wherein the implant comprises a body made of a flexible material.

37. The system of claim 34, wherein at least a portion of the implant comprises hydrogel.

38. The system of claim 34, wherein the implant is expandable upon implantation.