Medicament delivery device

• US 8,075,517 B2
• Filed: 05/29/2009
• Issued: 12/13/2011
• Est. Priority Date: 06/11/2008
• Status: Active Grant

• Current Assignee: Shl Medical AG
• Original Assignee: SHL Group AB
• Inventors: Karlsson, Sebastian, Elmén, Gunnar
• Primary Examiner(s): Lucchesi, Nicholas D
• Assistant Examiner(s): Vu, Quynh-Nhu H
• Application Number:
  US12/996,232
• Publication Number:
  US 20110077589A1
• Time in Patent Office: 928 Days
• Field of Search: 604/68, 604/70, 604 82- 92, 604/165.02, 604134-137, 604/181, 604/183, 604/187, 604/191, 604/218
• US Class Current: 604/82
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2451 preventing delivery before mixing is completed, e.g. by locking mechanisms
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/422 Desensitising skin

Abstract

The present invention relates to medicament delivery device comprising a generally tubular distal housing part (19); a generally tubular medicament container holder (16); a medicament container (18); a plunger rod (32); resilient force; an actuation means (34) comprising flexible locking means and an activation button; a release means (40); and a resilient means (60) characterized in that said plunger rod comprises a number of stop engagements (38) arranged on its outer circumferential surface and arranged to co-act with corresponding stop engagements (37) on the flexible locking means, such that when said activation button is proximally depressed said stop engagement (37) on said flexible locking means come out of contact from one stop engagement (38) of the plunger rod; and such that when said activation button (48) is released, said resilient means (60) forces the activation button and thereby the flexible locking means to move distally such that said stop engagements (37) on said flexible locking means come into contact with another stop engagement (38) of the plunger rod.

Claims

1. A medicament delivery device, comprising:

a generally tubular distal housing part;

a generally tubular medicament container holder having opposite distal and proximal ends, wherein the distal end is releasably connected to the distal housing part, and the proximal end is releasably connected to a delivery member;

a medicament container having at least one slidable stopper, wherein the container is arranged within the container holder;

a plunger rod having opposite proximal and distal ends and arranged within the distal housing part, wherein the proximal end of the plunger rod abuts the at least one slidable stopper;

a resilient force mechanism operably connected to the plunger rod for driving the plunger rod and thereby the at least one slidable stopper toward a proximal end of the device;

an actuation mechanism, comprising a flexible locking device releasably connected to the plunger rod for holding the plunger rod and thereby the resilient force mechanism in a pre-tensioned state, and an activation button distally protruding from the distal housing part;

a release mechanism slidably displaceable around the flexible locking device between a first position, in which the release mechanism completely surrounds the flexible locking device, and a second position, in which the release mechanism partially surrounds the flexible locking device after the release mechanism is distally displaced by the container holder when the container holder is displaced into the distal housing part;

wherein the flexible locking device is arranged to be released from the plunger rod only after the release mechanism is moved from the first position to the second position and the activation button is proximally depressed, such that the flexible locking device comes completely out of contact with the release mechanism; and

a resilient device arranged surrounding the release mechanism and to act axially on the actuation mechanism;

wherein the plunger rod comprises a number of stop engagements arranged on its outer circumferential surface to co-act with corresponding stop engagements arranged on the flexible locking device, such that when the activation button is proximally depressed, stop engagements on the flexible locking device come out of contact with a stop engagement on the plunger rod, and such that when the activation button is released, the resilient device forces the activation button and thereby the flexible locking device to move distally such that stop engagements on the flexible locking device come into contact with another stop engagement on the plunger rod.

2. The medicament delivery device of claim 1, wherein the flexible locking device includes flexible tongues, the stop engagements on the flexible locking device are inwardly directed protrusions, and the stop engagements on the plunger rod are circumferential grooves.

3. The medicament delivery device of claim 2, wherein the medicament container is a multi-chamber container and includes at least two substances.

4. The medicament delivery device of claim 3, wherein the distal housing part comprises a mix engagement device arranged to cooperate with a corresponding mix engagement device arranged on the distal end of the container holder, such that distal displacement of the container holder in relation to the distal housing part causes distal displacement of the container in relation to the plunger rod, whereby the plunger rod forces the stopper to be proximally displaced, thereby mixing the substances within the container.

5. The medicament delivery device of claim 4, wherein the mix devices include threads.

6. The medicament delivery device of claim 1, wherein the stop engagements on the flexible locking device and the stop engagements on the plunger rod are circumferential and produce an audible indication as long as a continuous medicament delivery is in progress.

7. A medicament delivery device, comprising:

a generally tubular distal housing part;

a generally tubular medicament container holder having opposite distal and proximal ends, wherein the distal end is releasably connected to the distal housing part, and the proximal end is releasably connected to a delivery member;

a medicament container having at least one slidable stopper, wherein the container is arranged within the container holder;

a plunger rod having opposite proximal and distal ends and arranged within the distal housing part, wherein the proximal end of the plunger rod abuts the at least one slidable stopper;

a resilient force mechanism operably connected to the plunger rod for driving the plunger rod and thereby the at least one slidable stopper toward a proximal end of the device;

an actuation mechanism, comprising a flexible locking device releasably connected to the plunger rod for holding the plunger rod and thereby the resilient force mechanism in a pre-tensioned state, and an activation button distally protruding from the distal housing part;

a release mechanism slidably displaceable around the flexible locking device between a first position, in which the release mechanism completely surrounds the flexible locking device, and a second position, in which the release mechanism partially surrounds the flexible locking device after the release mechanism is distally displaced by the container holder when the container holder is displaced into the distal housing part;

wherein the flexible locking device is arranged to be released from the plunger rod only after the release mechanism is moved from the first position to the second position and the activation button is proximally depressed, such that the flexible locking device comes completely out of contact with the release mechanism; and

a resilient device arranged surrounding the release mechanism and to act axially on the actuation mechanism;

wherein the plunger rod comprises a number of stop engagements arranged on its outer circumferential surface to co-act with corresponding stop engagements arranged on the flexible locking device, such that when the activation button is proximally depressed, stop engagements on the flexible locking device come out of contact with a stop engagement on the plunger rod, and such that when the activation button is released, the resilient device forces the activation button and thereby the flexible locking device to move distally such that stop engagements on the flexible locking device come into contact with another stop engagement on the plunger rod.

8. The medicament delivery device of claim 7, wherein the medicament container is a multi-chamber container and includes at least two substances.

9. The medicament delivery device of claim 8, wherein the distal housing part comprises a mix engagement device arranged to cooperate with a corresponding mix engagement device arranged on the distal end of the container holder, such that distal displacement of the container holder in relation to the distal housing part causes distal displacement of the container in relation to the plunger rod, whereby the plunger rod forces the stopper to be proximally displaced, thereby mixing the substances within the container.

10. The medicament delivery device of claim 9, wherein the mix devices include threads.

11. The medicament delivery device of claim 7, wherein the stop engagements on the flexible locking device and the stop engagements on the plunger rod are circumferential and produce an audible indication as long as a continuous medicament delivery is in progress.