Air-in-line and pressure detection

• US 8,075,546 B2
• Filed: 05/08/2007
• Issued: 12/13/2011
• Est. Priority Date: 07/07/2000
• Status: Active Grant

• Current Assignee: Mack Ventures, Inc.
• Original Assignee: Mack Ventures, Inc.
• Inventors: Patel, Keena B., Carlisle, Jeffrey A.
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US11/745,797
• Publication Number:
  US 20070288176A1
• Time in Patent Office: 1,680 Days
• Field of Search: 604 65- 67, 604/131, 604/154, 604/156, 604/30, 604/31, 604/134, 604/135, 604/32, 604/122, 604/48, 604/500, 128/DIG.12, 128/DIG.13
• US Class Current: 604/500
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/3355 Controlling downstream pump pressure
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066

Abstract

Methods and apparatus for air content and pressure measurement of sample fluid, especially sample fluid in association with an infusion pump. Volume change in a chamber as the chamber transitions between negative and positive pressure relates to the air content in the chamber. In particular, in an infusion pump, the volume change of infusion fluid as it transitions between being under negative pressure and positive pressure within a cassette central chamber, e.g., pumping chamber, relates to the air content in the infusion fluid. The outlet pressure of the cassette central chamber, e.g., blood pressure, can be monitored based on the cassette central chamber pressure.

Claims

1. A method of measuring air content in a sample fluid comprising:

determining a base volume change between zero or a negative pressure and a positive pressure in a chamber;

determining a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid; and

determining air content of the sample fluid by comparing the sample volume change and the base volume change; and

wherein the chamber has an inlet valve, an outlet valve, and an assembly connected to a pressure source, and the assembly comprises a cassette piston.

2. The method of claim 1, wherein the pressure source comprises a motor connected to the piston and generates negative pressure.

3. The method of claim 1, wherein the pressure source comprises a spring connected to the piston and generates positive pressure.

4. The method of claim 1, wherein the sample fluid flows into the chamber the pressure source generates negative pressure.

5. The method of claim 1, wherein the chamber is part of an infusion pump.

6. The method of claim 1, wherein the inlet valve and the outlet valve are closed when the pressure source generates positive pressure.

7. The method of claim 1, wherein the determination of the base volume change and the sample volume change includes determining a position of the cassette piston.

8. The method of claim 7, wherein the determination of the position of the cassette piston includes using an optical position sensor.

9. The method of claim 1 further comprising adjusting a fluid flow rate through the chamber based on an air/fluid content proportion in a given stroke of the cassette piston to compensate for the air content detected in the sample fluid.

10. The method of claim 1 further comprising determining an effective amount of fluid that is pumped out of the chamber based on the determined air content.

11. A method of measuring air content in a sample fluid comprising:

determining a base volume change between zero or a negative pressure and a positive pressure in a chamber;

determining a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid; and

determining air content of the sample fluid by comparing the sample volume change and the base volume change; and

wherein the chamber is closed at the positive pressure.

12. A method of measuring air content in a sample fluid comprising:

determining a base volume change between zero or a negative pressure and a positive pressure in a chamber;

determining a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid; and

determining air content of the sample fluid by comparing the sample volume change and the base volume change; and

wherein the determination of the base volume change is repeated for one or more times and a lower than average value is selected as the base volume change.

13. A method of measuring air content in a sample fluid comprising:

determining a base volume change between zero or a negative pressure and a positive pressure in a chamber;

determining a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid; and

determining air content of the sample fluid by comparing the sample volume change and the base volume change; and

wherein the air content of the sample fluid is related to the sample volume change minus the base volume change.

14. A method of measuring air content in a sample fluid comprising:

determining a base volume change between zero or a negative pressure and a positive pressure in a chamber;

determining a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid; and

determining air content of the sample fluid by comparing the sample volume change and the base volume change; and

calculating an accumulated air content of more than one sample fluids over a period of time.

15. The method of claim 14 further comprising comparing the accumulated air content to a predetermined value.

16. A method of measuring air content in a sample fluid comprising:

determining a base volume change between zero or a negative pressure and a positive pressure in a chamber;

determining a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid; and

determining air content of the sample fluid by comparing the sample volume change and the base volume change; and

wherein the determining of the base volume change comprises determining a median base volume change with more than one sample of an infusion fluid.

17. The method of claim 16, wherein the determining of the median base volume change comprises determining a median base volume change with 11 contiguous samples of an infusion fluid.

18. The method of claim 16, wherein the sample fluid is a sample of the infusion fluid.

19. An apparatus for air content measurement of a sample fluid comprising:

a central chamber;

an assembly moving in and out of the central chamber;

a pressure source connected to the assembly, and wherein the pressure source comprises a motor which generates a negative pressure in the central chamber and pumps fluid into the central chamber via the assembly, and a spring which generates a positive pressure in the central chamber and pumps fluid out of the central chamber via the assembly;

a position sensor connected to the assembly, wherein the position sensor determines a position change of the assembly; and

a processor connected to the position sensor, wherein the processor receives the position change of the assembly, calculates a base volume change between zero or a negative pressure and a positive pressure in the central, and a sample volume change between zero or a negative pressure and the positive pressure in the central chamber with a sample fluid, wherein the air content of the sample fluid is related to the sample volume change minus the base volume change.

20. The apparatus of claim 19, wherein the assembly is a cassette piston.

21. The apparatus of claim 19, wherein the central chamber comprises an inlet valve and an outlet valve.

22. The apparatus of claim 21, wherein the inlet valve and the outlet valve are closed when the pressure source generates positive pressure.

23. The apparatus of claim 19, wherein the central chamber is part of an infusion pump.

24. The apparatus of claim 19, wherein the position sensor is an optical position sensor.

25. The apparatus of claim 19, wherein the processor further compares the air content to a predetermined value.

26. The apparatus of claim 25 further comprising an alarming device connected to the processor, wherein the processor activates the alarming device when the air content equals or is beyond the predetermined value.

27. The apparatus of claim 26, wherein the processor prevents fluid from leaving the central chamber when the air content equals or is beyond the predetermined value.

28. The apparatus of claim 27 further comprising an outlet valve controlling fluid flow out of the central chamber, wherein the processor closes the outlet valve and turns off the motor when the air content equals or is beyond the predetermined value.

29. The apparatus of claim 19, wherein the processor calculates the air content at different time points and generates an accumulated air content over a period of time.

30. The apparatus of claim 29, wherein the processor further compares the accumulated air content with a predetermined value.

31. The apparatus of claim 30 further comprising an alarming device connected to the processor, wherein the processor activates the alarming device when the accumulated air content equals or is beyond the predetermined value.

32. The apparatus of claim 31, wherein the processor prevents fluid from leaving the central chamber when the accumulated air content equals or is beyond the predetermined value.

33. The apparatus of claim 32 further comprising an outlet valve controlling fluid flow out of the central chamber, wherein the processor closes the outlet valve and turns off the motor when the accumulated air content equals or is beyond the predetermined value.

34. The apparatus of claim 19, wherein the processor calculates the base volume change by calculating a median base volume change of more than one sample of an infusion fluid.

35. The apparatus of claim 34, wherein the processor calculates the bases volume change by calculating a median base volume change of 11 contiguous samples of an infusion fluid.

36. The apparatus of claim 34, wherein the sample fluid is a sample of the infusion fluid.

37. A method of measuring air content in a sample fluid comprising:

determining a base volume change between zero or a negative pressure and a positive pressure in a chamber;

determining a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid; and

determining air content of the sample fluid by comparing the sample volume change and the base volume change; and

wherein the sample fluid is a body fluid of a mammal.

38. The method of claim 37, wherein the mammal is a human.

39. The method of claim 37, wherein the body fluid is blood.

40. The method of claim 37, wherein the body fluid is blood in a vessel selected from the group consisting of artery, vein, and capillary.

41. A method of measuring air content in a sample fluid comprising:

providing a chamber having an inlet valve, an outlet valve, and an assembly connected to a pressure source operable to draw and pump the sample fluid into and out of, respectively, the chamber;

determining air content of the sample fluid based on a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber; and

wherein the determining the air content comprises comparing a) a base volume change between zero or a negative pressure and a positive pressure in a chamber, and b) a sample volume change between zero or the negative pressure and the positive pressure in the chamber with a sample fluid.

42. The method of claim 41, wherein the determining the air content comprises the sample volume change minus the base volume change.

43. The method of claim 41, wherein the determining the base volume change comprises determining the base volume change based on one or more sample fluids and selecting a lower than average value as the base volume change.

44. The method of claim 41, wherein the determining the base volume change comprises determining a median base volume change based on more than one sample fluid.

45. A method of measuring air content in a sample fluid comprising:

providing a chamber having an inlet valve, an outlet valve, and an assembly connected to a pressure source operable to draw and pump the sample fluid into and out of, respectively, the chamber;

determining air content of the sample fluid based on a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber; and

wherein the determining the air content comprises determining an accumulated air content of more than one sample fluid over a period of time.

46. The method of claim 45 further comprising comparing the accumulated air content to a predetermined value.

47. A method of measuring air content in a sample fluid comprising:

providing a chamber having an inlet valve, an outlet valve, and an assembly connected to a pressure source operable to draw and pump the sample fluid into and out of, respectively, the chamber;

determining air content of the sample fluid based on a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber; and

adjusting a fluid flow rate through the chamber based on an air/fluid content proportion in a given stroke of the assembly to compensate for the air content detected in the sample fluid.

48. A method of measuring air content in a sample fluid comprising:

providing a chamber having an inlet valve, an outlet valve, and an assembly connected to a pressure source operable to draw and pump the sample fluid into and out of, respectively, the chamber;

determining air content of the sample fluid based on a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber; and

determining an effective amount of fluid that is pumped out of the chamber based on the determined air content.

49. A method of measuring air content in a sample fluid comprising:

providing a chamber having an inlet valve, an outlet valve, and an assembly connected to a pressure source operable to draw and pump the sample fluid into and out of, respectively, the chamber;

determining air content of the sample fluid based on a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber; and

wherein the determining comprises determining a position of the assembly.

50. The method of claim 49, wherein the assembly comprises a cassette piston.

51. The method of claim 49, wherein the chamber is part of an infusion pump.

52. The method of claim 49, wherein the determining the position of the assembly comprises determining the position of the assembly using a position sensor.

53. A method of measuring air content in a sample fluid comprising:

providing a chamber having an inlet valve, an outlet valve, and an assembly connected to a pressure source operable to draw and pump the sample fluid into and out of, respectively, chamber;

determining air content of the sample fluid based on a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber; and

wherein the sample fluid is a sample of the infusion fluid.

54. A method of measuring air content in a sample fluid comprising:

providing a chamber having an inlet valve, an outlet valve, and an assembly connected to a pressure source operable to draw and pump the sample fluid into and out of, respectively, the chamber;

determining air content of the sample fluid based on a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber; and

wherein the sample fluid is a body fluid of a mammal.

55. The method of claim 54, wherein the mammal is a human.

56. The method of claim 54, wherein the body fluid is blood.

57. The method of claim 54, wherein the body fluid is blood in a vessel selected from the group consisting of artery, vein, and capillary.

58. An apparatus for air content measurement of a sample fluid comprising:

a central chamber;

an assembly moving in and out of the central chamber;

a pressure source connected to the assembly for generating a negative pressure in the central chamber and drawing fluid into the central chamber via the assembly, and for generating a positive pressure in the central chamber and pumping fluid out of the central chamber via the assembly;

a position sensor connected to the assembly, wherein the position sensor determines a position change of the assembly; and

a processor operably connected to the position sensor for receiving the position change of the assembly, and the processor being operable to determine an air content of a sample fluid in the central chamber based on the positional change of the assembly.

59. The apparatus of claim 58, wherein the processor is operable to determine an air content of the sample fluid based on the positional change of the assembly corresponding to a volume change of the sample fluid as it transitions between being under a negative pressure and a positive pressure within the chamber.

60. The apparatus of claim 58, wherein the processor is operable to determine an air content of the sample fluid based on the positional change of the assembly by calculating a base volume change between zero or a negative pressure and a positive pressure in the central chamber, and a sample volume change between zero or a negative pressure and the positive pressure in the central chamber with a sample fluid.

61. The apparatus of claim 60, wherein the processor is operable to calculate the base volume change by calculating a median base volume change of more than one sample fluid.

62. The apparatus of claim 61, wherein the processor is operable to calculate the base volume change by calculating a median base volume change of 11 contiguous fluid samples.

63. The apparatus of claim 61, wherein the sample fluid is a sample of an infusion fluid.

64. The apparatus of claim 58, wherein the assembly is a cassette piston.

65. The apparatus of claim 58, wherein the central chamber is part of an infusion pump.

66. The apparatus of claim 58, wherein the position sensor is an optical position sensor.

67. The apparatus of claim 58, wherein the processor is operable to compare the air content to a predetermined value.

68. The apparatus of claim 67 further comprising an alarming device connected to the processor, wherein the processor is operable to activate the alarming device when the air content equals or is beyond the predetermined value.

69. The apparatus of claim 68, wherein the processor prevents fluid from leaving the central chamber when the air content equals or is beyond the predetermined value.

70. The apparatus of claim 69, wherein the processor is operable to calculate the air content at different time points and generate an accumulated air content over a period of time.

71. The apparatus of claim 70, wherein the processor is operable to compare the accumulated air content with a predetermined value.

72. The apparatus of claim 71, further comprising an alarming device connected to the processor, wherein the processor is operable to activate the alarming device when the accumulated air content equals or is beyond the predetermined value.

73. The apparatus of claim 72, wherein the processor prevents fluid from leaving the central chamber when the accumulated air content equals or is beyond the predetermined value.

74. The apparatus of claim 58, wherein the sample fluid is a body fluid of a mammal.

75. The apparatus of claim 74, wherein the body fluid is blood.

76. The apparatus of claim 75, wherein the body fluid is blood in a vessel selected from the group consisting of artery, vein, and capillary.