Process for preparing antimicrobial plastic bodies having improved long-time performance

• US 8,075,823 B2
• Filed: 04/24/2007
• Issued: 12/13/2011
• Est. Priority Date: 07/30/1999
• Status: Expired due to Term

• Current Assignee: Andreas Hirsch, Guggenbichler J. Peter
• Original Assignee: Andreas Hirsch, Guggenbichler J. Peter
• Inventors: Guggenbichler, J. Peter, Hirsch, Andreas
• Primary Examiner(s): Michener, Jennifer K.
• Assistant Examiner(s): Slawski, Magali P.
• Application Number:
  US11/789,232
• Publication Number:
  US 20070194483A1
• Time in Patent Office: 1,694 Days
• Field of Search: 264/129, 264/131, 424/421, 424/618, 427/2.1, 427/2.24, 427/2.3, 427/2.31
• US Class Current: 264/176.1
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/126 having a macromolecular matrix
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: C08J 2375/04 Polyurethanes
• CPC Class Codes: C08J 3/2053 the additives only being premixed with a liquid phase
• CPC Class Codes: C08J 7/043 Improving the adhesiveness of the coatings per se, e.g. forming primers adhesives in the form of films or foils characterised by the primer layers between the polymer carriers and the adhesives C09J7/50
• CPC Class Codes: C08J 7/06 with compositions not containing macromolecular substances
• CPC Class Codes: C08K 2003/0806 Silver
• CPC Class Codes: C08K 3/08 Metals
• CPC Class Codes: C08K 9/12 Adsorbed ingredients , e.g. ingredients on carriers
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

The present invention relates to processes for preparing an antimicrobial plastic body, said processes comprising molding a precursor and being characterized in that prior to molding at least one component of the precursor is treated with a metal colloid.

Claims

1. A process for preparing an antimicrobial plastic body comprising colloidal metal, one or several polymer materials and one or several inorganic additives, said process comprising the steps of

(A) preparing a metal colloid solution comprising colloidal metal and organic stability protective agent, wherein the colloidal metal consists of metal particles,

(B) treating at least one of the one or several inorganic additives with the metal colloid solution to form a suspension,

(C) removing organic stability protective agent from the suspension of step B) to obtain a solid, drying the solid, and adding the one or several polymer materials to obtain a precursor, and

(D) molding the precursor obtained in step (C) to form the antimicrobial plastic body.

2. The process as claimed in claim 1 wherein the one or several polymer materials includes polyurethane.

3. The process as claimed in claim 1 wherein several inorganic additives are treated with the metal colloid solution to form the suspension.

4. The process as claimed in claim 1 wherein said inorganic additives comprise barium sulfate, calcium sulfate, strontium sulfate, titanium oxide, aluminum oxide, silicon oxide, zeolites, mica, talcum or kaolin.

5. The process as claimed in claim 1 wherein additionally at least one of the one or several polymer materials are treated with the metal colloid solution.

6. The process as claimed in claim 1 wherein the colloidal metal is colloidal silver.

7. The process as claimed in claim 1 wherein removing organic stability protective agent from the suspension of step (B) comprises filtering the suspension.

8. The process as claimed in claim 1 wherein after adding the one or several polymer materials in step (C), the amount of organic stability protective agent in the precursor is less than 0.182 wt %.

9. The process as claimed in claim 1 wherein after adding the one or several polymer materials in step (C), the amount of organic stability protective agent in the precursor is less than 0.056 wt %.

10. The process as claimed in claim 1 wherein molding the precursor in step (D) comprises mixing, kneading, extruding, injection molding or hot press molding.

11. The process as claimed in claim 1 wherein the organic protective agent is gelatin or starch.

12. The process as claimed in claim 1 wherein the antimicrobial plastic body is a medical device.

13. The process as claimed in claim 12 wherein the antimicrobial plastic body is a catheter.

14. A process for preparing an antimicrobial plastic body comprising colloidal metal, one or several polymer materials and one or several inorganic additives, said process comprising the steps of

(A) preparing a metal colloid solution comprising colloidal metal and organic stability protective agent, wherein the colloidal metal consists of metal particles,

(B) treating at least one of the one or several polymer materials with the metal colloid solution to form a suspension,

(C) removing organic stability protective agent from the suspension of step B) to obtain a solid, drying the solid, and adding the one or several inorganic additives to obtain a precursor, and

(D) molding the precursor obtained in step (C) to form the antimicrobial plastic body.

15. The process as claimed in claim 14 wherein the one or several polymer materials includes polyurethane.

16. The process as claimed in claim 14 wherein said inorganic additives comprise barium sulfate, calcium sulfate, strontium sulfate, titanium oxide, aluminum oxide, silicon oxide, zeolites, mica, talcum or kaolin.

17. The process as claimed in claim 14 wherein additionally at least one of the one or several inorganic additives are treated with the metal colloid solution.

18. The process as claimed in claim 14 wherein the colloidal metal is colloidal silver.

19. The process as claimed in claim 14 wherein the antimicrobial plastic body is a medical device.

20. The process as claimed in claim 19 wherein the antimicrobial plastic body is a catheter.