Intracranial neural interface system

• US 8,078,252 B2
• Filed: 04/22/2010
• Issued: 12/13/2011
• Est. Priority Date: 10/21/2003
• Status: Active Grant

• Current Assignee: Daryl R. Kipke, Garell P. Charles, Jaimie Henderson, Jamille Hetke, Justin C. Williams
• Original Assignee: Daryl R. Kipke, Garell P. Charles, Jaimie Henderson, Jamille Hetke, Justin C. Williams
• Inventors: Kipke, Daryl R., Williams, Justin C., Hetke, Jamille, Henderson, Jaimie, Garell, P. Charles
• Primary Examiner(s): COHEN, LEE S
• Application Number:
  US12/765,630
• Publication Number:
  US 20110046470A1
• Time in Patent Office: 600 Days
• Field of Search: 600/378, 607/116
• US Class Current: 600/378
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/37514 Brain implants
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.

Claims

1. An implantable neural interface node, comprising:

a base insertable into a mammalian cranium, wherein the base includes side walls that define a lumen;

a plurality of neuroprobe assemblies coupled to the base; and

an electronic component coupled to at least one of the neuroprobe assemblies;

wherein the base further includes a shelf and the electronic component includes a circuit board on the shelf within the base, wherein the circuit board is substantially flat and circular and defines an open center.

2. The implantable neural interface node of claim 1, wherein the side walls of the base are adapted to extend towards a surface of the cranium.

3. The implantable neural interface node of claim 2, wherein the side walls of the base are adapted to extend towards a lower surface of the cranium.

4. The implantable neural interface node of claim 2, wherein the base includes a top surface adapted to extend towards a top surface of the cranium, further comprising a plug that forms a seal over the top surface of the base and around an edge of the lumen of the base.

5. The implantable neural interface node of claim 1, wherein the base includes a bottom surface adapted to extend part way through the cranium.

6. The implantable neural interface node of claim 1, wherein the base includes a top surface adapted to extend towards a top surface of the cranium.

7. The implantable neural interface node of claim 6, wherein the top surface is adapted to be flush with the top surface of the cranium.

8. The implantable neural interface node of claim 6, wherein the top surface includes a flange.

9. The implantable neural interface node of claim 6, further comprising a plug, coupled to the base, that forms a seal over the top surface of the base.

10. The implantable neural interface node of claim 9, wherein the plug includes a cover that forms a seal around an edge of the lumen of the base.

11. The implantable neural interface node of claim 1, wherein the base is sized to fit in a hole in the cranium.

12. The implantable neural interface node of claim 11, wherein the hole in the cranium has a diameter greater than 0.5 centimeters.

13. The implantable neural interface node of claim 1, wherein at least one neuroprobe assembly is positioned within the lumen of the base.

14. The implantable neural interface node of claim 13, wherein at least one neuroprobe assembly includes a microelectrode array.

15. The implantable neural interface node of claim 13, wherein at least one neuroprobe assembly includes a fluidic component.

16. The implantable neural interface node of claim 1, wherein the electronic component is stacked in the base.

17. The implantable neural interface node of claim 16, wherein the circuit board is stacked in the base.

18. The implantable neural interface node of claim 1, wherein the electronic component is coupled to the base.

19. The implantable neural interface node of claim 1, wherein the electronic component is permanently coupled to the base.