Computerized methods for evaluating response latency and accuracy in the diagnosis of attention deficit hyperactivity disorder

• US 8,078,253 B2
• Filed: 02/20/2003
• Issued: 12/13/2011
• Est. Priority Date: 02/22/2002
• Status: Active Grant

• Current Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Original Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Inventors: Lowen, Steven B., Teicher, Martin H.
• Primary Examiner(s): MEHTA, PARIKHA SOLANKI
• Application Number:
  US10/370,809
• Publication Number:
  US 20030233032A1
• Time in Patent Office: 3,218 Days
• Field of Search: 600/383, 600/384, 600/558, 600/300, 600/595, 128/898
• US Class Current: 600/407
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/1127 using markers
• CPC Class Codes: A61B 5/162 Testing reaction times
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Provided are methods for diagnosing the presence, type, or severity of a dementia in a human subject. The methods involve using a computer-based system to assess impairment of certain cognitive and motor functions that are indicative of Alzheimer'"'"'s disease and other forms of dementia.

Claims

1. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject;

(d) storing in said computer the instances of device activation by said subject;

(e) determining an accuracy parameter of device activation;

(f) determining a response time parameter of device activation;

(g) calculating a test value based on (e) and (f) as follows;

T≡

(accuracy)−

[25+response time/10)],

wherein a positive value of T indicates a normal test result and a negative value of T indicates an abnormal test result characteristic of Attention Deficit Hyperactivity Disorder; and

(h) using the calculation of step (g) to generate a report of said results.

8. The method of claim 1, further comprising the steps of:

(h) using a motion analysis device connected to said computer to record movements of said subject during presentation of said visual images;

(i) storing the record of said movements in said computer;

(j) analyzing said recorded movements for abnormal deviations; and

(k) using the analysis of step (j) together with the test value to diagnose Attention Deficit Hyperactivity Disorder.

14. The method of claim 1, 2, or 3, wherein said computer is connected to a second computer via a network and said instructions or said images are conveyed to said subject across the network.

15. The method of claim 14, wherein the network is selected from a global computer network, a local area network, a wide area network, an intranet, and an extranet.

16. The method of claim 1, 2, or 3, wherein said visual images are selected from the group consisting of symbols, numbers, letters, and shapes.

17. The method of claim 16, wherein said visual images are stars.

18. The method of claim 17, wherein said visual images are five-pointed stars and eight-pointed stars.

19. The method of claim 17, wherein said subject is instructed to activate said device when a star having a specified number of points is displayed on said monitor.

2. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject;

(d) storing in said computer the instances of device activation by said subject;

(e) determining an accuracy parameter of device activation;

(f) determining a response time parameter of device activation;

(g) calculating an Adjusted Latency as follows;

Adjusted Latency=(response time)−

10×

(accuracy−

Q),

where the value of Q is selected to represent a typical accuracy value, and wherein the adjusted latency discriminates between normal test results and abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(h) using the calculation of step (g) to generate a report of said results.

4. The method of claim 2, wherein the Adjusted Latency is calculated using a typical accuracy value, Q, characteristic of said subject'"'"'s gender.

5. The method of claim 2, wherein the Adjusted Latency is calculated using a typical accuracy value, Q, characteristic of said subject'"'"'s age.

9. The method of claim 2, further comprising the steps of:

(h) using a motion analysis device connected to said computer to record movements of said subject during presentation of said visual images;

(i) storing the record of said movements in said computer;

(j) analyzing said recorded movements for abnormal deviations; and

(k) using the analysis of step (j) together with the Adjusted Latency to diagnose Attention Deficit Hyperactivity Disorder.

3. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject;

(d) storing in said computer the instances of device activation by said subject;

(e) determining an accuracy parameter of device activation;

(f) determining a response time parameter of device activation;

(g) calculating an Adjusted Accuracy as follows;

Adjusted Accuracy=Accuracy+10×

(Latency−

R)

where the value of R is selected to represent a typical response time value and Latency is the average response time of said subject, and wherein the adjusted accuracy discriminates between normal test results and abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(h) using the calculation of step (g) to generate a report of said results.

6. The method of claim 3, wherein the Adjusted Accuracy is calculated using a typical response time value, R, characteristic of said subject'"'"'s gender.

7. The method of claim 3, wherein the Adjusted Accuracy is calculated using a typical response time value, R, characteristic of said subject'"'"'s age.

10. The method of claim 3, further comprising the steps of:

(h) using a motion analysis device connected to said computer to record movements of said subject during presentation of said visual images;

(i) storing the record of said movements in said computer;

(j) analyzing said recorded movements for abnormal deviations; and

(k) using the analysis of step (j) together with the Adjusted Accuracy to diagnose Attention Deficit Hyperactivity Disorder.

11. The method of claim 8, 9 or 10, wherein said motion analysis device is a video camera.

12. The method of claim 11, wherein said camera is an infrared camera capable of detecting an infrared reflective marker.

13. The method of claim 12, wherein at least one infrared reflective marker is placed onto said subject.

20. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject;

(d) transmitting to a computer for analysis data from the instances of device activation by said subject; and

(e) receiving the results of said analysis, wherein said analysis comprises determining an accuracy parameter of device activation;

determining a response time parameter of device activation; and

calculating a test value based on said accuracy parameter and said response parameter as follows;

T≡

(accuracy)−

[25+response time/10)],

wherein a positive value of T indicates a normal test result and a negative value of T indicates an abnormal test result characteristic of Attention Deficit Hyperactivity Disorder; and

(f) using said analysis to generate a report of said results.

21. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject;

(d) transmitting to a computer for analysis data from the instances of device activation by said subject; and

(e) receiving the results of said analysis, wherein said analysis comprises determining an accuracy parameter of device activation;

determining a response time parameter of device activation; and

calculating an Adjusted Latency as follows;

Adjusted Latency≡

(response time)−

10×

(accuracy−

Q),

where the value of Q is selected to represent a typical accuracy value, and wherein the adjusted latency discriminates between normal test results and abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(f) using said analysis to generate a report of said results.

26. The method of claim 21 or 24, wherein the Adjusted Latency is calculated using a typical accuracy value, Q, characteristic of said subject'"'"'s age or gender.

22. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject;

(d) transmitting to a computer for analysis data from the instances of device activation by said subject; and

(e) receiving the results of said analysis, wherein said analysis comprises determining an accuracy parameter of device activation;

determining a response time parameter of device activation; and

calculating an Adjusted Accuracy as follows;

Adjusted Accuracy=Accuracy+10×

(Latency−

R)

where the value of R is selected to represent a typical response time value and Latency is the average response time of said subject, and wherein the adjusted accuracy discriminates between normal test results and abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(f) using said analysis to generate a report of said results.

27. The method of claim 22 or 25, wherein the Adjusted Accuracy is calculated using a typical response time value, R, characteristic of said subject'"'"'s age or gender.

23. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(I) providing data having been collected by the steps of (a) placing, in proximity to a subject, (i) a monitor can be activated to a computer, and (ii) a device that is controllable by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject; and

(d) recording the instances of device activation by said subject to produce said data;

(II) performing an analysis of said data, said analysis comprising determining an accuracy parameter of device activation;

determining a response time parameter of device activation; and

calculating a test value based on said accuracy parameter and said response parameter as follows;

T≡

(accuracy)−

[25+response time/10)],

wherein a positive value of T indicates a normal test result and a negative value of T indicates an abnormal test result characteristic of Attention Deficit Hyperactivity Disorder; and

(III) using the analysis of step (II) to generate a report of said results.

24. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(I) providing data having been collected by the steps of (a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject; and

(d) recording the instances of device activation by said subject to produce said data;

(II) performing an analysis of said data, said analysis comprising determining an accuracy parameter of device activation;

determining a response time parameter of device activation; and

calculating an Adjusted Latency as follows;

Adjusted Latency=(response time)−

10×

(accuracy−

Q),

where the value of Q is selected to represent a typical accuracy value, and wherein the adjusted latency discriminates between normal test results and abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(III) using the analysis of step (II) to generate a report of said results.

25. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(I) providing data having been collected by the steps of (a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject; and

(d) recording the instances of device activation by said subject to produce said data;

(II) performing an analysis of said data, said analysis comprising determining an accuracy parameter of device activation;

determining a response time parameter of device activation; and

calculating an Adjusted Accuracy as follows;

Adjusted Accuracy=Accuracy+10×

(Latency×

R)

where the value of R is selected to represent a typical response time value and Latency is the average response time of said subject, and wherein the adjusted accuracy discriminates between normal test results and abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(III) using the analysis of step (II) to generate a report of said results.

28. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject;

(d) transmitting to a computer for analysis data from the instances of device activation by said subject; and

(e) receiving the results of said analysis, wherein said analysis comprises determining an accuracy parameter of device activation;

determining a response time parameter of device activation;

calculating a composite test value based on said accuracy parameter and said response time parameter; and

on the basis of said composite test value determining whether said test results are normal test results or abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(f) using said analysis to generate a report of said results.

29. A method of diagnosing Attention Deficit Hyperactivity Disorder in a subject, said method comprising the steps of:

(I) providing data having been collected by the steps of (a) placing, in proximity to a subject, (i) a monitor that is connected to a computer, and (ii) a device that can be activated by said subject and that is also connected to said computer;

(b) presenting to said subject instructions with respect to activating said device in response to visual images on said monitor, wherein said subject is instructed to activate said device when a specified image is displayed on said monitor;

(c) presenting to said subject said visual images on said monitor while recording instances of device activation by said subject; and

(d) recording the instances of device activation by said subject to produce said data;

(II) performing an analysis of said data, said analysis comprising determining an accuracy parameter of device activation;

determining a response time parameter of device activation;

calculating a composite test value based on said accuracy parameter and said response time parameter; and

on the basis of said composite test value determining whether said test results are normal test results or abnormal test results characteristic of Attention Deficit Hyperactivity Disorder; and

(III) using the analysis of step (II) to generate a report of said results.