System and method for identifying disease-influencing genes
First Claim
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1. A method for generating groups of individuals useful in researching influence of a disease on said individuals, comprising:
- selecting individuals having a risk factor for a disease;
providing to each individual a communications apparatus;
transmitting a computer program containing queries and predefined response choices to said communications apparatus, wherein said computer program when executed causes said communications apparatus to present said queries and predefined response choices to each individual via a display of said communications apparatus and collect responses to said queries, including at least one of the predefined response choices presented on the display of the communications apparatus, from each individual via user input buttons of the communications apparatus;
receiving said responses to the queries from the individuals through the communications apparatus, said responses communicating information about the individuals;
storing the responses of each individual in a database;
defining a plurality of groups by categorizing the individuals having similar profiles based on the responses, wherein categorizing the individuals into groups includes one or more phenotypic classifications;
after defining said groups, receiving genotype information representative of individuals in each of said groups;
comparing said genotype information between said groups; and
generating a report for presentation on a display that represents a subset of said genotype information associated with each of said groups, wherein differences in said genotype information between said groups is expressed in terms of phenotypic classifications.
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Abstract
The present invention describes a system and method of using individuals'"'"' behavioral and physiologic information to identify disease-influencing genes.
400 Citations
17 Claims
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1. A method for generating groups of individuals useful in researching influence of a disease on said individuals, comprising:
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selecting individuals having a risk factor for a disease; providing to each individual a communications apparatus; transmitting a computer program containing queries and predefined response choices to said communications apparatus, wherein said computer program when executed causes said communications apparatus to present said queries and predefined response choices to each individual via a display of said communications apparatus and collect responses to said queries, including at least one of the predefined response choices presented on the display of the communications apparatus, from each individual via user input buttons of the communications apparatus; receiving said responses to the queries from the individuals through the communications apparatus, said responses communicating information about the individuals; storing the responses of each individual in a database; defining a plurality of groups by categorizing the individuals having similar profiles based on the responses, wherein categorizing the individuals into groups includes one or more phenotypic classifications; after defining said groups, receiving genotype information representative of individuals in each of said groups; comparing said genotype information between said groups; and generating a report for presentation on a display that represents a subset of said genotype information associated with each of said groups, wherein differences in said genotype information between said groups is expressed in terms of phenotypic classifications. - View Dependent Claims (2, 3, 4, 5, 15, 16, 17)
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6. A system for generating groups of individuals useful in researching influence of a disease on said individuals, comprising:
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a communications apparatus operable by an individual; and a communication network in signal communication with the communications apparatus and a server, a workstation configured to send scripted queries and predefined response choices, a genotyping system configured to provide genotype information representative of the individual, and a patient profile system configured to receive responses from the individual and genotype information analyses via the communications network and the server, wherein the server transmits a computer program containing the scripted queries and predefined response choices to the communications apparatus, the computer program when executed causes the communications apparatus to present the scripted queries and predefined response choices to the individual via a display of said communications apparatus and collect responses to the queries containing information about the individual and at least one of the predefined response choices presented on the display of said communications apparatus, whereby the genotype information is compared based upon groups formed by categorizing individuals having a risk factor for a disease using the responses to the scripted queries in the patient profile system to identify one or more individuals having similar profiles, wherein categorizing the individuals into groups includes one or more phenotypic classifications, and differences in said genotype information between said groups is expressed in terms of phenotypic classifications. - View Dependent Claims (7, 8, 13)
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9. A system for identifying groups of individuals useful in researching influence of disease on said individuals, comprising:
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at least one communications apparatus in signal communication with a monitoring device configured to measure physiologic and environmental conditions, the communications apparatus and monitoring device being operable by at least one individual; and a communication network in signal communications with each communications apparatus and a server, a workstation configured to send scripted queries and predefined response choices, a genotyping system configured to provide genotype information representative of the at least one individual, and a patient profile system configured to receive responses and measurements from the at least one individual and genotype information analyses via the communications network and the server, wherein the server transmits a computer program containing the scripted queries and predefined response choices to the communications apparatus the computer program when executed causes the communications apparatus to present the scripted queries and predefined response choices to the individual via a display of the communications apparatus and collect responses to the scripted queries containing information about the individual and at least one of the predefined response choices presented on the display of said communications apparatus, whereby the genotype information representative of the at least one individual is compared based upon groups formed by categorizing individuals having a risk factor for a disease using the responses and measurements to the scripted queries in the patient profile system to identify one or more individuals having similar profiles, wherein categorizing the individuals into groups includes one or more phenotypic classifications, and differences in said genotype information between said groups is expressed in terms of phenotypic classifications. - View Dependent Claims (10, 11, 12, 14)
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Specification