Method and implantable apparatus for the intra-osseal monitoring of biological substances in the bone marrow

• US 8,080,003 B1
• Filed: 08/25/2010
• Issued: 12/20/2011
• Est. Priority Date: 02/02/2006
• Status: Expired due to Fees

• Current Assignee: Paunceforte Technologies, LLC
• Original Assignee: Paunceforte Technologies, LLC
• Inventors: Burton, Charles Victor, Lovett, Robert Harold
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US12/868,329
• Time in Patent Office: 482 Days
• Field of Search: 600309-344
• US Class Current: 604/891.1
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6878 Bone
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A method for monitoring and controlling biological substances found in the bloodstream include implanting in-vivo a pedestal such that a sensor mounted on the pedestal extends into the bone marrow for sensing the biological substance. A transmitter is included for transmitting signals from the sensor to a receiver. An apparatus that includes a monitoring device and a drug delivery device and components to communicate between the monitoring and drug delivery devices.

Claims

1. A method for monitoring and controlling biological substance concentrations in the bloodstream of a patient comprising:

implanting in-vivo a monitoring device comprising a pedestal and a sensor such that the sensor mounted on the pedestal extends into bone marrow for sensing the biological substance concentration;

sensing the concentration of biological substance in the bloodstream with the sensor;

implanting in-vivo a drug delivery device into the bone marrow;

transmitting signals from the sensor to a receiver relating to the biological substance concentration in the bloodstream; and

transmitting signals from the receiver to the drug delivery device such that a dose of a drug is administered to the bone marrow of the patient to control the biological substance concentration in the bloodstream.

2. The method of claim 1 wherein the monitoring device and the drug delivery device are integrated into a single device.

3. The method of claim 1 wherein the monitoring device and the drug delivery device are spaced apart from each other when implanted.

4. The method of claim 1 wherein the monitoring device and the drug delivery device are implanted in the patient'"'"'s posterior iliac crest.

5. The method of claim 1 wherein the monitoring device is implanted in the patient'"'"'s posterior iliac crest and the drug delivery device is implanted in the contra-lateral posterior iliac crest.

6. The method of claim 1 wherein the signals transmitted from the sensor to the receiver are transmitted over a wireless connection.

7. The method of claim 1 wherein the signals transmitted from the sensor to the receiver are transmitted over a wired connection.

8. The method of claim 1 wherein the signals transmitted from the receiver to the drug delivery device are over a wired connection.

9. The method of claim 1 wherein the signals transmitted from the receiver to the drug delivery device are over a wireless connection.

10. The method of claim 1 wherein the biological substance is cerebrospinal fluid.