Calibration procedures and devices for investigation biological systems

• US 8,080,407 B2
• Filed: 11/04/2010
• Issued: 12/20/2011
• Est. Priority Date: 03/11/2002
• Status: Expired due to Term

• Current Assignee: Janusz B. Pawliszyn
• Original Assignee: Janusz B. Pawliszyn
• Inventors: Pawliszyn, Janusz B.
• Primary Examiner(s): LAM, ANN Y
• Application Number:
  US12/939,360
• Publication Number:
  US 20110067482A1
• Time in Patent Office: 411 Days
• Field of Search: None
• US Class Current: 435/287.1
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 17/3403 Needle locating or guiding means guides for suture needles A61B17/0482; guiding or tracking by nuclear magnetic resonance G01R33/285
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/15 Devices for taking samples of blood hypodermic syringes A61M5/178
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/151 Devices specially adapted for taking samples of capillary blood, e.g. by lancets , needles or blades
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: B01L 2300/046 Function or devices integrated in the closure
• CPC Class Codes: B01L 2300/069 Absorbents; Gels to retain a fluid
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 2300/0838 Capillaries
• CPC Class Codes: B01L 3/5025 for parallel transport of multiple samples
• CPC Class Codes: G01N 1/405 by adsorption or absorption
• CPC Class Codes: G01N 2001/4016 : being a selective membrane, e.g. dialysis or osmosis
• CPC Class Codes: G01N 2030/009 : Extraction
• CPC Class Codes: G01N 2030/062 : extracting sample from raw material
• CPC Class Codes: G01N 2035/1053 : for separating part of the liquid, e.g. filters, extraction phase
• CPC Class Codes: G01N 35/028 : having reaction cells in the form of microtitration plates
• CPC Class Codes: H01J 49/0431 : for liquid samples interfaces to liquid chromatographs G01N30/7233
• CPC Class Codes: Y10S 436/807 : Apparatus included in process claim, e.g. physical support structures
• CPC Class Codes: Y10T 436/105831 : Protein or peptide standard or control [e.g., hemoglobin, etc.]
• CPC Class Codes: Y10T 436/25 : including sample preparation
• CPC Class Codes: Y10T 436/255 : including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems.

Claims

1. A device for continuous extraction and analysis of a component in a sample constituting a feeding fluid, said device comprising a semipermeable membrane in a housing, said feeding fluid passing on one side of said semipermeable membrane and a stripping fluid simultaneously passing on the other side of said semipermeable membrane, said stripping fluid containing an inert calibrant, said stripping fluid constituting a carrier to deliver to an analytical device said inert calibrant remaining in said stripping fluid and said component passing from said feeding fluid through said semipermeable structure into said stripping fluid.

2. The device as claimed in claim 1 wherein said stripping fluid is a gas and analytical instrument is a gas chromatograph.