Long lasting synthetic exendin-4 peptide conjugates

• US 8,080,516 B2
• Filed: 06/29/2005
• Issued: 12/20/2011
• Est. Priority Date: 05/17/1999
• Status: Expired due to Fees

• Current Assignee: ConjuChem LLC (Colabor Group, Inc.)
• Original Assignee: ConjuChem LLC (Colabor Group, Inc.)
• Inventors: Bridon, Dominique P., L'Archeveque, Benoit, Holmes, Darren L., St. Pierre, Serge, LeBlanc, Anouk
• Primary Examiner(s): CHEN, STACY BROWN
• Application Number:
  US11/170,967
• Publication Number:
  US 20060009377A1
• Time in Patent Office: 2,365 Days
• Field of Search: None
• US Class Current: 514/1.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 47/643 Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: C07K 14/005 from viruses
• CPC Class Codes: C07K 14/57563 Vasoactive intestinal peptide [VIP]; Related peptides
• CPC Class Codes: C07K 14/605 Glucagons
• CPC Class Codes: C12N 2740/16122 New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.

Claims

1. A compound according to the following formula:

2. A pharmaceutical composition comprising a compound according to the following formula:

5. The method of claim 2, wherein the reacting step occurs in vivo.

3. A method of making a conjugate comprising the step of reacting a compound according to the following formula:

4. The method of claim 3, wherein said reacting occurs between a compound according to the following formula:

6. The method of claim 3, wherein the reacting step occurs ex vivo.

7. The method of claim 3, wherein the albumin is human serum albumin.

8. The conjugate produced by the method of claim 3.

9. The conjugate produced by the method of claim 4.

10. The conjugate produced by the method of claim 7.

11. A pharmaceutical composition comprising the conjugate of claim 8 in association with a physiologically acceptable medium.

12. A pharmaceutical composition comprising the conjugate of claim 9 in association with a physiologically acceptable medium.

13. A pharmaceutical composition comprising the conjugate of claim 10 in association with a physiologically acceptable medium.

14. The method of claim 4, wherein the albumin is serum albumin.

15. The method of claim 14, wherein the reacting step occurs ex vivo.

16. The method of claim 4, wherein the albumin is human serum albumin.

17. The method of claim 16, wherein the reacting step occurs ex vivo.

18. The conjugate produced by claim 15.

19. The conjugate produced by claim 15.

20. The conjugate produced by claim 17.

21. A pharmaceutical composition comprising the conjugate of claim 18 in association with a physiologically acceptable medium.

22. A pharmaceutical composition comprising the conjugate of claim 19 in association with a physiologically acceptable medium.

23. A pharmaceutical composition comprising the conjugate of claim 20 in association with a physiologically acceptable medium.