Method and a system for determination of particles in a liquid sample
First Claim
1. A method for the assessment of at least one quantity parameter and/or at least one quality parameter of biological particles in blood or blood product, comprisingapplying a volume of a liquid sample representing the blood or blood product to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior,exposing, onto an array of active detection elements, an at least one-dimensional spatial representation of electromagnetic signals having passed from the domain, the representation being one which is detectable as an intensity by individual active detection elements, under conditions which will permit processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals, and wherein the spatial representation exposed onto the array of detection elements is subject to such a linear enlargement that the ratio of a linear dimension of the image on the array of detection elements to the original linear dimension in the exposing domain is smaller than 10:
- 1, wherein the sample is at stand still during exposure,processing the intensities detected by the detection elements in such a manner that signals from the biological particles are identified as distinct from background signals,and correlating the results of the processing to the at least one quantity parameter and/or the at least one quality parameter of the blood or blood product.
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Abstract
The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
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Citations
58 Claims
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1. A method for the assessment of at least one quantity parameter and/or at least one quality parameter of biological particles in blood or blood product, comprising
applying a volume of a liquid sample representing the blood or blood product to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, exposing, onto an array of active detection elements, an at least one-dimensional spatial representation of electromagnetic signals having passed from the domain, the representation being one which is detectable as an intensity by individual active detection elements, under conditions which will permit processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals, and wherein the spatial representation exposed onto the array of detection elements is subject to such a linear enlargement that the ratio of a linear dimension of the image on the array of detection elements to the original linear dimension in the exposing domain is smaller than 10: - 1, wherein the sample is at stand still during exposure,
processing the intensities detected by the detection elements in such a manner that signals from the biological particles are identified as distinct from background signals, and correlating the results of the processing to the at least one quantity parameter and/or the at least one quality parameter of the blood or blood product. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
- 1, wherein the sample is at stand still during exposure,
Specification