Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution
First Claim
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1. A method of determining concentration of a fluorescent indicator that is indocyanine green (ICG) having a concentration CICG within the cardiovascular system of a subject comprising:
- a. administering to the cardiovascular system a detectable amount of the indicator that fluoresces when illuminated;
b. illuminating a portion of the cardiovascular system with an excitation light of a first wavelength and causing the administered indicator to emit an emergent fluorescence light of a second wave length;
c. detecting the intensity (x) of the excitation light that is reflected by or transmitted through a portion of the cardiovascular system;
d. detecting the intensity (y) of the emergent fluorescence light;
e. determining the ratio (y)/(x);
f. determining the concentration (CICG) of the fluorescence indicator in the cardiovascular system based on the determined ratio (y)/(x), wherein the concentration of the fluorescence indicator is proportional to the ratio; and
g. determining a ratio CICG/CHb of indocyanine green concentration (CICG) to the blood hemoglobin concentration (CHb) wherein the ratio CICG/CHb is proportional to the change of the ratio (y)/(x).
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Abstract
A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.
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9 Claims
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1. A method of determining concentration of a fluorescent indicator that is indocyanine green (ICG) having a concentration CICG within the cardiovascular system of a subject comprising:
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a. administering to the cardiovascular system a detectable amount of the indicator that fluoresces when illuminated; b. illuminating a portion of the cardiovascular system with an excitation light of a first wavelength and causing the administered indicator to emit an emergent fluorescence light of a second wave length; c. detecting the intensity (x) of the excitation light that is reflected by or transmitted through a portion of the cardiovascular system; d. detecting the intensity (y) of the emergent fluorescence light; e. determining the ratio (y)/(x); f. determining the concentration (CICG) of the fluorescence indicator in the cardiovascular system based on the determined ratio (y)/(x), wherein the concentration of the fluorescence indicator is proportional to the ratio; and g. determining a ratio CICG/CHb of indocyanine green concentration (CICG) to the blood hemoglobin concentration (CHb) wherein the ratio CICG/CHb is proportional to the change of the ratio (y)/(x). - View Dependent Claims (2, 3)
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4. A system for determining concentration of a fluorescent indicator that is indocyanine green (ICG) having a concentration CICG within the cardiovascular system of a subject comprising:
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a. an illumination source configured to be positioned proximately to at least one blood vessel of the cardiovascular system to provide a first wavelength of light to excite an indicator within the cardiovascular system to cause the indicator to emit a second wavelength of light; b. at least one photodetector configured to be positioned proximate to the cardiovascular system of the subject and configured to detect information regarding the intensity (x) of the excitation light that is reflected by or transmitted through a portion of the cardiovascular system and to detect information regarding the intensity (y) of the emergent fluorescence light; and c. a computing system configured; to receive the detected intensity information from the photodetector; ii. to determine the concentration (CICG) of the indicator, wherein (CICG) is proportional to the ratio (y)/(x); and iii. to determine a concentration ratio CICG/CHb of indocyanine green concentration (CICG) to the blood hemoglobin concentration (CHb), wherein the ratio CICG/CHb is proportional to the change of the ratio (y)/(x). - View Dependent Claims (5, 6, 7, 8, 9)
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Specification