Methods for measuring cross-sectional areas and pressure gradients in luminal organs
First Claim
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1. A method for measuring the cross-sectional area of a targeted treatment site, comprising:
- introducing an impedance device into a treatment site, the impedance device selected from the group consisting of an impedance catheter and an impedance wire;
providing electrical current flow to the treatment site through the device;
injecting a first solution of a first compound having a first conductivity into the treatment site;
measuring a first conductance value at the treatment site using the device, the first conductance value indicative of a bolus of the first solution;
injecting a second solution of a second compound having a second conductivity into the treatment site, wherein the second conductivity does not equal the first conductivity;
measuring a second conductance value at the treatment site using the device, the second conductance value indicative of a bolus of the second solution; and
calculating the cross-sectional area of the treatment site based on the first and second conductance values, the conductivities of the first and second solutions, and a known distance between two detection electrodes of the impedance device.
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Abstract
The present disclosure comprises a system, catheter and method for measuring the cross-sectional areas and pressure gradients in any hollow organ, such as, for example, blood vessels. One embodiment of such a method includes the steps of introducing an impedance catheter into a treatment site, providing electrical current flow to the treatment site, injecting a first solution and measuring a first conductance value, injecting a second solution and measuring a second conductance value, and calculating the cross-sectional area of the treatment site, in part, based on the first and second conductance values.
118 Citations
29 Claims
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1. A method for measuring the cross-sectional area of a targeted treatment site, comprising:
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introducing an impedance device into a treatment site, the impedance device selected from the group consisting of an impedance catheter and an impedance wire; providing electrical current flow to the treatment site through the device; injecting a first solution of a first compound having a first conductivity into the treatment site; measuring a first conductance value at the treatment site using the device, the first conductance value indicative of a bolus of the first solution; injecting a second solution of a second compound having a second conductivity into the treatment site, wherein the second conductivity does not equal the first conductivity; measuring a second conductance value at the treatment site using the device, the second conductance value indicative of a bolus of the second solution; and calculating the cross-sectional area of the treatment site based on the first and second conductance values, the conductivities of the first and second solutions, and a known distance between two detection electrodes of the impedance device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method for measuring the cross-sectional area of a targeted treatment site, comprising:
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introducing an impedance catheter into a treatment site; providing electrical current flow to the treatment site through the catheter; injecting a first solution having a first conductivity into the treatment site; measuring a first conductance value at the treatment site using the catheter; injecting a second solution having a second conductivity into the treatment site, wherein the second conductivity does not equal the first conductivity; measuring a second conductance value at the treatment site using the catheter; calculating the cross-sectional area of the treatment site based on the first and second conductance values, the conductivities of the first and second solutions, and a known distance between two detection electrodes of the impedance catheter; selecting an appropriately-sized stent based on the cross-sectional area value of the treatment site; positioning the stent around a balloon attached to the catheter; introducing the catheter with the stent positioned thereon into the treatment site; inflating the balloon with a fluid to implant the stent into the treatment site; providing electrical current into the fluid filling the balloon at various degrees of balloon distension; measuring the conductance of the fluid inside the balloon; and calculating the cross-sectional area of the balloon lumen.
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29. A method for measuring the cross-sectional area of a blood vessel and implanting a stent therein, comprising:
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introducing an impedance device into a blood vessel, the impedance device selected from the group consisting of an impedance catheter and an impedance wire; providing electrical current flow through the device within the blood vessel; injecting a first solution of a first compound having a first conductivity into the blood vessel; measuring a first conductance value within the blood vessel at or near the site of injection of the first solution using the device, the first conductance value indicative of a bolus of the first solution; injecting a second solution of a second compound having a second conductivity into the blood vessel, wherein the second conductivity does not equal the first conductivity; measuring a second conductance value within the blood vessel at or near the site of the injection of the second solution using the device, the second conductance value indicative of a bolus of the second solution; calculating the cross-sectional area of the blood vessel based on the first and second conductance values, the conductivities of the first and second solutions, and a known distance between two detection electrodes of the impedance device; selecting an selecting an appropriately-sized stent based on the cross-sectional area of the blood vessel; and implanting the stent into the blood vessel.
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Specification