Conversion of nitrogen dioxide (NO 2 ) to nitric oxide (NO)

• US 8,083,997 B2
• Filed: 07/10/2009
• Issued: 12/27/2011
• Est. Priority Date: 08/18/2004
• Status: Expired due to Fees

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Rounbehler, David R., Fine, David H.
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US12/500,929
• Publication Number:
  US 20090285731A1
• Time in Patent Office: 900 Days
• Field of Search: 422/120, 422/122, 951/02, 951/05, 951/20, 128/200.14, 128/203.12
• US Class Current: 422/120
• CPC Class Codes: A61D 7/04 Devices for anaesthetising animals by gases or vapours; Inhaling devices
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 2016/102 Measuring a parameter of the content of the delivered gas
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/08 Bronchodilators
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.

Claims

1. An apparatus for converting nitrogen dioxide to nitric oxide comprising a receptacle including an inlet, an outlet and an antioxidant, wherein the inlet is configured to receive a gas flow comprising nitrogen dioxide and fluidly communicate the gas flow through the receptacle to the outlet, such that the gas flow contacts the antioxidant inside the receptacle, and the antioxidant converts the nitrogen dioxide in the gas flow to nitric oxide.

2. The apparatus of claim 1, wherein the receptacle further comprises a surface-active material.

3. The apparatus of claim 2, wherein the surface-active material comprises a substrate that retains water.

4. The apparatus of claim 2, wherein the surface-active material comprises a silica gel.

5. The apparatus of claim 2, wherein the antioxidant is included on the surface active material.

6. The apparatus of claim 1, wherein the receptacle comprises a cartridge.

7. The apparatus of claim 1, wherein the antioxidant comprises ascorbic acid, alpha tocopherol or gamma tocopherol.

8. An apparatus for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:

a permeation cell having liquid nitrogen dioxide and capable of diffusing gaseous nitrogen dioxide into a gas flow; and

a receptacle including an inlet, an outlet and an antioxidant, wherein the inlet is configured to receive the gas flow comprising nitrogen dioxide and fluidly communicate the gas flow through the receptacle to the outlet, such that the gas flow contacts the antioxidant inside the receptacle, and the antioxidant converts the nitrogen dioxide in the gas flow to nitric oxide.

9. The apparatus of claim 8, wherein the receptacle is a first receptacle, the apparatus further comprising a second receptacle including a second inlet, a second outlet and a second antioxidant, wherein the second inlet is configured to receive the gas flow comprising nitrogen dioxide and fluidly communicate the gas flow through the receptacle to the second outlet, such that the gas flow contacts the second antioxidant inside the second receptacle, and the second antioxidant converts the nitrogen dioxide in the gas flow to nitric oxide.

10. The apparatus of claim 9, wherein the antioxidant in the first receptacle and the second antioxidant are the same.

11. The apparatus of claim 9, wherein the second receptacle further comprises a second suface-active material.

12. The apparatus of claim 11, wherein the surface-active material in the first receptacle and the second surface-active material are the same.

13. The apparatus of claim 9, further comprising a flexible bag operable to inflate and deflate as the mammal breathes, and wherein the second receptacle is positioned between the flexible bag and a point at which the gas flow including nitric oxide is delivered to the mammal.

14. The apparatus of claim 8, wherein the receptacle further comprises a surface-active material.

15. The apparatus of claim 14, wherein the surface-active material comprises a substrate that retains water.

16. The apparatus of claim 14, wherein the surface-active material comprises a silica gel.

17. The apparatus of claim 14, wherein the antioxidant is on the surface active material.

18. The apparatus of claim 8, further comprising an air pump capable of generating the gas flow, wherein the permeation cell is configured to receive the gas flow generated by the air pump.

19. The apparatus of claim 18, wherein the air pump is portable.

20. The apparatus of claim 8, further comprising an oxygen-enrichment device capable of supplying oxygen in the gas flow, wherein the permeation cell is configured to receive the gas flow enriched by the oxygen-enrichment device.

21. The apparatus of claim 8, wherein the receptacle comprises a cartridge.

22. The apparatus of claim 8, wherein the antioxidant comprises ascorbic acid, alpha tocopherol or gamma tocopherol.