Non-curling polyhydroxyalkanoate sutures

• US 8,084,125 B2
• Filed: 12/11/2009
• Issued: 12/27/2011
• Est. Priority Date: 08/03/2004
• Status: Active Grant

• Current Assignee: Tepha Incorporated (Becton, Dickinson & Co)
• Original Assignee: Tepha Incorporated (Becton, Dickinson & Co)
• Inventors: Rizk, Said
• Primary Examiner(s): Edwards, N.
• Application Number:
  US12/636,129
• Publication Number:
  US 20100093237A1
• Time in Patent Office: 746 Days
• Field of Search: 428/364, 606/208
• US Class Current: 428/364
• CPC Class Codes: A61L 17/105 Polyesters not covered by A61L17/12
• CPC Class Codes: C08G 63/06 derived from hydroxycarboxylic acids
• CPC Class Codes: D01F 6/625 derived from hydroxy-carboxylic acids, e.g. lactones
• CPC Class Codes: Y10T 428/2913 Rod, strand, filament or fiber
• CPC Class Codes: Y10T 442/10 Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]

Abstract

Absorbable polyester fibers, braids, and surgical meshes with improved handling properties have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available and have a decreased tendency to curl, in the preferred embodiment, due to the inclusion of relaxation and annealing steps following extrusion and orientation of the fiber. Filaments prepared according to these methods are characterized by the following physical properties: (i) elongation to break from about 17% to about 85% (ii) Young'"'"'s modulus of less than 350,000 psi, (iii) knot to straight ratio (knot strength/tensile strength) of 55-80% or (iv) load at break from 1100 to 4200 grams.

Claims

1. A polymeric filament comprising 4-hydroxybutyrate or copolymers thereof, wherein the filament has a knot strength to tensile strength ratio of 55-80%, an elongation to break from 17% to 85%, a Young'"'"'s modulus of less than 350,000 psi, and a load at break between 1100 and 4200 g, and is produced by extrusion, orientation, relaxation, shrinking, and annealing of the extruded filament.

2. The filament of claim 1 wherein the filament has an elongation to break from 17% to 85%.

3. The filament of claim 1 wherein the filament has a Young'"'"'s modulus of less than 350,000 psi.

4. The filament of claim 1 in the form of a suture.

5. The filament of claim 1 formed into a mesh.

6. The filament of claim 1 in the form of a medical device.

7. The filament of claim 1 in the form of a device for repair of tendons or ligaments.