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Identification of molecular sequence signatures and methods involving the same

  • US 8,084,197 B2
  • Filed: 05/08/2007
  • Issued: 12/27/2011
  • Est. Priority Date: 09/19/1996
  • Status: Expired due to Fees
First Claim
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1. A method for determining whether a nucleic acid sample from a patient contains nucleic acid encoding a signature sequence characteristic of a pathogen said method comprising:

  • obtaining a nucleic acid containing sample from said patient;

    providing a probe array comprising a first plurality of polynucleotide probe sets each probe set defining a different reference nucleotide sequence wherein each reference nucleotide sequence signature is between 15 and 30 bases in length and codes for a different amino acid sequence that is a signature sequence characteristic of said pathogen; and

    a second plurality of polynucleotide probe sets each probe set defining a degenerate set of nucleotide sequences encoding each different amino acid sequence and wherein the probe set defining said degenerate set comprises at least 25% of the nucleotide sequences encoding said degenerate set;

    hybridizing said nucleic acid sample to said probe array to generate a hybridization pattern; and

    analyzing said hybridization pattern to determine if nucleic acid encoding a sequence signature characteristic of said pathogen is present in the sample.

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