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Amelioration of heterophile antibody immunosensor interference

  • US 8,084,272 B2
  • Filed: 03/25/2009
  • Issued: 12/27/2011
  • Est. Priority Date: 03/25/2009
  • Status: Active Grant
First Claim
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1. A method of reducing interference from heterophile antibodies in an analyte immunoassay, comprising:

  • (a) contacting a whole blood sample with a dry reagent comprising non-human IgM or fragments thereof to yield an amended sample having a non-human IgM concentration of at least 20 μ

    g/mL or equivalent fragment concentration; and

    (b) performing an electrochemical immunoassay on the amended sample to determine the concentration of said analyte in said sample, wherein the amended sample has sufficiently sequestered heterophile antibodies therein.

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