Systems and methods for a multiple angle light scattering (MALS) instrument having two-dimensional detector array
First Claim
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1. A system for detecting and identifying a particle in a liquid, the system comprising:
- a tubular flow cell configured to carry a liquid medium, the flow cell comprising a target zone within the liquid medium, the particle carried into the target zone by the liquid medium;
a light source configured to generate a light beam and to direct the light beam through flow cell and into the target zone;
an optic configured to collect and reflect light scattered by a particle in the target zone, the optic comprising a reflective optic having a curved reflecting surface, the reflective optic optically coupled with the flow cell, the reflective optic is also configured to collect and reflect light scattered by a particle in the liquid medium in the target zone; and
a 2-dimensional detector camera configured to detect the reflected light.
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Abstract
A particle detection system uses a reflective optic comprising a curved surface to detect high angle scattered light generated by a particle in a liquid medium, when a laser beam is incident on the particle. When the particles transit the laser beam, light is scattered in all directions and is described by MIE scattering theory for particles about the size of the wavelength of light and larger or Rayleigh Scattering when the particles are smaller than the wavelength of light. By using the reflective optic, the scattered light can be detected over angles that are greater than normally obtainable.
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Citations
30 Claims
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1. A system for detecting and identifying a particle in a liquid, the system comprising:
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a tubular flow cell configured to carry a liquid medium, the flow cell comprising a target zone within the liquid medium, the particle carried into the target zone by the liquid medium; a light source configured to generate a light beam and to direct the light beam through flow cell and into the target zone; an optic configured to collect and reflect light scattered by a particle in the target zone, the optic comprising a reflective optic having a curved reflecting surface, the reflective optic optically coupled with the flow cell, the reflective optic is also configured to collect and reflect light scattered by a particle in the liquid medium in the target zone; and a 2-dimensional detector camera configured to detect the reflected light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for detecting and identifying a particle in a liquid, the system comprising:
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a tubular flow cell comprising a flowing liquid media and a target zone, the particle carried in the path of a light beam by the liquid media; a light source configured to generate the light beam and direct the light beam through the flow cell and into the target zone; an interface optic; a reflective optic configured to collect and reflect light scattered by a particle carried by the liquid media through the target zone, the optic comprising a reflective optic having a curved reflecting surface, the reflective optic is integral to the flow cell and the reflective optic optically coupled with the liquid medium in the target zone, the reflective optic configured to collect and reflect light scattered by a particle in the liquid medium in the target zone; and a 2-dimensional detector camera configured to detect the reflected light. - View Dependent Claims (14, 15, 16, 17, 18)
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19. A system for detecting and identifying a particle in a liquid, the system comprising:
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a tubular flow cell configured to carry a liquid medium, the flow cell comprising a target zone within the liquid medium, the particle carried into the target zone by the liquid medium; a light source configured to generate a light beam and to direct the light beam through the flow cell and into the target zone; an optic configured to collect and reflect light scattered by a particle in the target zone, the optic comprising a reflective optic having a curved reflecting surface, the reflective optic being integral to and optically coupled with the flow cell and wherein the reflective optic is also configured to collect and reflect light scattered by a particle in the liquid medium in the target zone; and a 2-dimensional detector camera configured to detect the reflected light. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification