Blood flow restorative and embolus removal methods

• US 8,088,140 B2
• Filed: 05/29/2009
• Issued: 01/03/2012
• Est. Priority Date: 05/19/2008
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Mindframe LLC (Medtronic Plc)
• Inventors: Ferrera, David A., Cragg, Andrew H., Fulkerson, John
• Primary Examiner(s): NGUYEN, TUAN VAN
• Application Number:
  US12/475,389
• Publication Number:
  US 20090292297A1
• Time in Patent Office: 949 Days
• Field of Search: 606/1, 606/108, 606/191, 606/192, 606/193, 606/194, 606/198, 606/200, 606/113, 623/1.15
• US Class Current: 606/200
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320783 through side-hole, e.g. sliding or rotating cutter inside catheter
• CPC Class Codes: A61B 2017/22039 eccentric
• CPC Class Codes: A61B 2017/22094 for crossing total occlusions, i.e. piercing
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0097 Harpoon-shaped
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: A61M 25/09025 with sliding mandrils

Abstract

Methods for restoring blood flow in occluded blood vessels are disclosed. The methods can include accessing an artery with a catheter system and locating an occluded zone within the artery caused by an embolus. The catheter system can include a microcatheter and a blood flow restoration device or an embolus removal device having a self-expandable member configured to be delivered through the microcatheter in a compressed configuration and to be deployed to an expanded configuration upon retraction of the microcatheter. The methods can include deploying the self-expandable member at the location of the occluded zone such that the self-expandable member engages and captures the embolus upon deployment of the self-expandable member and removing the embolus by withdrawing the blood flow restoration device or the embolus removal device.

Claims

1. A method for restoring blood flow in an occluded cerebral blood vessel of a patient during acute ischemic stroke, comprising:

accessing an cerebral blood vessel having an occluded zone with a catheter system, the catheter system comprising a microcatheter and an embolus removal device;

wherein the embolus removal device comprises a self-expandable member configured to be delivered through the microcatheter in a compressed configuration and deployed to an expanded configuration upon retraction of the microcatheter,

wherein the self-expandable member comprises a generally cylindrical body having a cell structure configured to facilitate embolus attachment to the self-expandable member;

locating the occluded zone within the artery caused by an embolus;

advancing the catheter system to the location of the occluded zone;

deploying the self-expandable member to the expanded configuration at the location of the occluded zone by retracting the microcatheter such that the self-expandable member engages and captures the embolus upon deployment of the self-expandable member,

wherein the embolus is at least partially engaged and captured on an external surface of the self-expandable member; and

removing the embolus by withdrawing the embolus removal device.

2. The method of claim 1, wherein a first end of the self-expandable member operatively abuts the embolus.

3. The method of claim 1, wherein engaging the embolus facilitates autolysis of the embolus or any fragments of the embolus remaining in the artery.

4. The method of claim 1, the removing step further comprising moving the engaged embolus down the intracranial tree to a more stable location.

5. The method of claim 1, wherein the cell structure of the body of the self-expandable member comprises variable cell size at different portions of the body.

6. The method of claim 1, wherein a distal end of the self-expandable member of the embolus removal device is open in the expanded configuration.

7. The method of claim 1, wherein said self-expandable member is permanently coupled to a distal end of a delivery member by a plurality of tether lines.

8. The method of claim 1, wherein the embolus resides at least partially within the capture device upon being captured.

9. The method of claim 5, wherein the cell size of the body of the capturing device is larger in the middle section of the body.

10. A method for restoring blood flow in an occluded cerebral blood vessel of a patient, comprising:

accessing a cerebral artery having an occluded zone with a catheter system, the catheter system comprising a microcatheter and a blood flow restoration device,

wherein the blood flow restoration device comprises a distal self-expandable capture device and a proximal delivery member,

wherein the distal self-expandable capture device is eccentrically coupled to the proximal delivery member by a plurality of tether lines,

wherein the distal self-expandable capture device is configured to be delivered through the microcatheter in a compressed configuration and deployed to an expanded configuration upon retraction of the microcatheter;

locating the occluded zone within the artery caused by an occlusive object;

advancing the catheter system to the location of the occluded zone;

deploying the distal self-expandable capture device to the expanded configuration at the location of the occluded zone by retracting the microcatheter such that the capture device engages and captures the occlusive object upon deployment of the capture device,

wherein the occlusive object is at least partially engaged and captured on an external surface of the capture device; and

removing the occlusive object by withdrawing the blood flow restoration device.

11. The method of claim 10, wherein the occluding object comprises any one of the following non-limiting examples:

an embolus, a thrombus, a blood clot, a calcified lesion, or any other obstruction within a blood vessel.

12. The method of claim 10, wherein the occlusive object resides at least partially within the capture device upon being captured.