Methods of reducing a viral infection and kits therefore
First Claim
1. A method for inhibiting sustained hepatitis C virus (HCV) replication in a host infected by HCV, said method comprising decreasing the expression of CD81 at the surface of cells from said host by administering a composition comprising a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) in the host infected by HCV, whereby the increased PCSK9 activity inhibits sustained HCV replication in the host, and wherein said PCSK9 comprises a sequence as set forth between residues 153 to 692 of SEQ ID NO:
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Abstract
A method for treating and/or preventing a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9)-susceptible viral infection comprising increasing a PCSK9 activity and/or expression in a biological system infected by the virus, whereby the increased PCSK9 activity and/or expression treats and/or prevents the viral infection in the biological system. Methods of classifying subjects, methods of screening and kits therefore.
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Citations
5 Claims
- 1. A method for inhibiting sustained hepatitis C virus (HCV) replication in a host infected by HCV, said method comprising decreasing the expression of CD81 at the surface of cells from said host by administering a composition comprising a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) in the host infected by HCV, whereby the increased PCSK9 activity inhibits sustained HCV replication in the host, and wherein said PCSK9 comprises a sequence as set forth between residues 153 to 692 of SEQ ID NO:
Specification