Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
First Claim
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1. An activated polyoxazoline-2 (POZ-2) derivative of the general structure
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Abstract
The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.
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16 Claims
- 1. An activated polyoxazoline-2 (POZ-2) derivative of the general structure
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