Sirtuin modulating compounds
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Abstract
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
76 Citations
13 Claims
- 1. A compound of the formula:
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2. A composition comprising a compound of the formula:
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3. A pharmaceutical composition comprising:
a. a compound of the formula;
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4. A packaged pharmaceutical comprising a compound of the formula:
Specification