Tissue discrimination and applications in medical procedures

• US 8,090,436 B2
• Filed: 10/29/2009
• Issued: 01/03/2012
• Est. Priority Date: 05/18/2000
• Status: Expired due to Term

• Current Assignee: Nuvasive Incorporated
• Original Assignee: Nuvasive Incorporated
• Inventors: Hoey, Michael, Stone, Corbett, Foley, Kevin
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Lloyd, Emily
• Application Number:
  US12/609,004
• Publication Number:
  US 20100049081A1
• Time in Patent Office: 796 Days
• Field of Search: 600/547, 600/554, 606/301
• US Class Current: 600/547
• CPC Class Codes: A61B 17/7001 Screws or hooks combined with longitudinal elements which do not contact vertebrae A61B17/7058 takes precedence
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 2017/00022 Sensing or detecting at the treatment site
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/4893 Nerves

Abstract

A system and method for discriminating tissue types, controlling the level of therapy to tissue, and determining the health of a known tissue by measuring the characteristics of an electrical signal applied to a conductive element located within or by the tissue. Additionally, the system and method may be used for determining whether the conductive tip of a pedicle probe or pedicle screw is located in one of cortical bone, cancellous bone, and cortical bone near a boundary with soft tissue, whether the conductive tip of a cannula is located adjacent to one of nerve tissue and annulus tissue, and whether the conductive tip of a cathode is located adjacent to one of nerve tissue and prostate gland tissue.

Claims

1. A system for preventing violation of a cortical wall of a pedicle during spine surgery, said pedicle including a cancellous core within said cortical wall, said system comprising:

(a) a screw configured for advancement and purchase into said pedicle and having a non-conductive shaft and a conductive tip; and

(b) a processor in electrical communication with the screw, the processor configured to direct application of an electrical signal to the conductive tip and determine at least one of the capacitance and impedance characteristics of the tissue adjacent to said conductive tip to determine whether said conductive tip lies within or adjacent cortical bone, cancellous bone, and cortical bone near the boundary with soft tissue.

2. The system of claim 1, wherein said conductive tip comprises a bi-polar electrode.

3. The system of claim 1, wherein the determined characteristics of the tissue further include a phase angle relationship between a voltage and current of the applied electrical signal.

4. The system of claim 1, wherein the applied electrical signal has a range of predetermined frequencies.

5. The system of claim 4, wherein the range of predetermined frequencies is from 400 KHz to 100 MHz.

6. The system of claim 1, wherein the applied signal has a fixed frequency.

7. The system of claim 1, wherein the applied electrical signal has a sliding frequency.

8. The system of claim 1, wherein the applied signal is a sinusoidal signal.

9. The system of claim 1, wherein the applied signal is a square wave signal.

10. The system of claim 1, further comprising an output element for communicating feedback regarding said measured characteristics.

11. The system of claim 1, further comprising an input device for receiving instructions from a user.

12. The system of claim 1, wherein said screw further comprises a conductive head.

13. A method for preventing violation of a cortical wall of a pedicle during spine surgery, said pedicle including a cancellous core within said cortical wall, comprising the steps of:

(a) advancing a pedicle screw into at least one of said cancellous core and said cortical wall of said pedicle during spine surgery, said pedicle screw having a conductive tip for measuring impedance;

(b) delivering an electrical signal to said conductive tip during step (a);

(c) measuring the impedance of at least one of said cancellous core and said cortical wall during step (a); and

(d) stopping the advancement of said pedicle screw based on a change in said measured impedance from step (c)to prevent a violation of said cortical wall by the continued advancement of said pedicle screw.

14. The method of claim 13, further comprising the step of communicating feedback to said user.

15. The method of claim 13, wherein the delivery of said electrical signal of step (b) and the measuring of impedance of step (c)are performed by a processor in electrical communication with said pedicle screw.

16. The method of claim 14, wherein the communication of feedback to said user is performed by an output element.

17. The method of claim 13, wherein said conductive tip comprises a bi-polar electrode.

18. The method of claim 13, wherein step (b) includes delivering said electrical signal with at least one of a fixed frequency and a sliding frequency.

19. A method for preventing violation of a cortical wall of a pedicle during spine surgery, said pedicle including a cancellous core within said cortical wall, comprising the steps of:

(a) advancing a pedicle screw through said cancellous core of said pedicle during spine surgery, said pedicle screw having a conductive tip for measuring impedance;

(b) measuring the impedance adjacent the conductive tip during step (a);

(c) viewing feedback from an output element; and

(d) stopping the advancement of said pedicle screw if said measured impedance indicates said conductive tip is not within said cancellous core to prevent a violation of said cortical wall by the continued advancement of said pedicle screw.

20. The method of claim 19, wherein the measuring of impedance of step (b) is performed by a processor in electrical communication with said pedicle screw.

21. The method of claim 19, wherein said output element is a computer display.

22. The method of claim 19, wherein said conductive tip comprises a bi-polar electrode.

23. The method of claim 19, wherein step (b) includes delivering an electrical signal to said conductive tip, said electrical signal having at least one of a fixed frequency and a sliding frequency.