Photochemical tissue bonding
First Claim
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1. A method for adhering tissue, comprising:
- contacting a tissue, a tissue substitute, and at least one photosensitizer agent to form a tissue-photosensitizer complex; and
applying electromagnetic energy to the tissue-photosensitizer complex in a manner effective to create covalent crosslinks between the tissue and tissue substitute, wherein the tissue or tissue substitute is not contacted with an adhesive comprising an exogenous protein or peptide which is crosslinked by the application of electromagnetic energy, thereby creating a seal having a tensile strength between the tissue and the tissue substitute.
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Abstract
Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.
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Citations
28 Claims
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1. A method for adhering tissue, comprising:
- contacting a tissue, a tissue substitute, and at least one photosensitizer agent to form a tissue-photosensitizer complex; and
applying electromagnetic energy to the tissue-photosensitizer complex in a manner effective to create covalent crosslinks between the tissue and tissue substitute, wherein the tissue or tissue substitute is not contacted with an adhesive comprising an exogenous protein or peptide which is crosslinked by the application of electromagnetic energy, thereby creating a seal having a tensile strength between the tissue and the tissue substitute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
- contacting a tissue, a tissue substitute, and at least one photosensitizer agent to form a tissue-photosensitizer complex; and
Specification