Ciliated stent-like-system

• US 8,092,549 B2
• Filed: 09/24/2004
• Issued: 01/10/2012
• Est. Priority Date: 09/24/2004
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hillis, W. Daniel, Ishikawa, Muriel Y., Tegreene, Clarence T., Wilson, Richa, Wood, Victoria Y. H., Wood, Lowell L. Jr.
• Primary Examiner(s): Stewart, Alvin J.
• Application Number:
  US10/949,186
• Publication Number:
  US 20060069425A1
• Time in Patent Office: 2,664 Days
• Field of Search: 623/23.7, 623/1.15, 623 11- 15, 623/23.65, 623/23.64, 604 8- 9, 600/37, 600/114, 600/109, 606/191, 606/192, 606/151, 606/157
• US Class Current: 623/23.64
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/043 Bronchi
• CPC Class Codes: A61F 2002/046 Tracheae
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2/00 Magnetotherapy

Abstract

A ciliated stent-like system and method of operating the same.

Claims

1. A device, comprising:

a flexible hollow portion with an outer surface and an inner surface;

a plurality of movable parts coupled to the inner surface of the flexible hollow portion; and

the plurality of movable parts configured to contact a material and including a control mechanism configured to induce controllable motion of the plurality of movable parts to generate a force for moving the material within the hollow portion.

2. The device of claim 1, wherein the flexible hollow portion comprises:

a substantially tubular or cylindrical structure.

3. The device of claim 2, wherein the a substantially tubular or cylindrical structure comprises:

at least one of a substantially expandable, or contractile structure.

4. The device of claim 2, wherein the substantially tubular or cylindrical structure flexible comprises:

an expandable mesh.

5. The device of claim 2, wherein the substantially tubular or cylindrical structure comprises:

a plurality of expandable segments coupled to the plurality of movable parts.

6. The device of claim 2, wherein the substantially tubular or cylindrical structure comprises:

one or more of a metal, silicon, polymer, plastic, organic, or biodegradable material.

7. The device of claim 2, wherein the substantially tubular or cylindrical structure further comprises:

a coating of one or more of a drug, a medicinal agent, a therapeutic agent, a biologically active agent, a chemical, a chemical compound, a surfactant, a steroid, a luminal-dilating agent, a luminal-contracting agent, an antibiotic or antifungal or antiviral agent, a protein, a nucleic acid or a polymer comprised of one or more nucleic acids, a macromolecule, a peptide, polymer, or a biodegradable material.

8. The device of claim 1, wherein the flexible hollow portion comprises:

a shape or configuration for placement in the location.

9. The device of claim 1, wherein the flexible hollow portion comprises:

one or more forks or branches.

10. The device of claim 1, wherein the flexible hollow portion comprises:

a substantially smooth inner surface.

11. The device of claim 1, wherein the flexible hollow portion comprises:

an inner surface with a low coefficient of friction operable for low-impedance flow of air or fluid.

12. The device of claim 1, wherein the flexible hollow portion comprises:

an outer surface with a surface modification operable for adhesion, adherence or positioning to the location in the host.

13. The device of claim 12, wherein the surface modification comprises:

one or more of a groove, bump, ridge, ring or contour.

14. The device of claim 1, wherein the host includes:

an animal or a plant.

15. The device of claim 1, wherein the plurality of movable parts comprises:

one or more of a gel, a hydrogel, a colloid, a polymer, an oscillating polymer, an electro-active polymer, a polymer, an electro- or magneto-strictive material, a linear motor-device, or a material coated with a biologically compatible material.

16. The device of claim 1, wherein the plurality of movable parts comprises:

a low-level gait or motion for moving fluid, particles, fluidized particles, mucus, exudate or debris.

17. The device of claim 1, wherein the plurality of movable parts comprises:

a high-level gait or motion for moving fluid, particles, fluidized particles, mucus, exudate, or debris.

18. The device of claim 1, wherein the control mechanism comprises:

an actuator, a motor, a biomolecular motor, or a device operable for providing motion coupled to the plurality of movable parts.

19. The device of claim 1, wherein the control mechanism comprises:

a MEMS device.

20. The device of claim 1, wherein the control mechanism comprises:

a magnetic material.

21. The device of claim 1, wherein the control mechanism comprises:

an electroactive polymer.

22. The device of claim 1, wherein the control mechanism comprises:

an electrorestrictive material.

23. The device of claim 1, wherein the device further comprises:

a mechanism for dispensing of at least one of a drug, a medicinal agent, a therapeutic agent, a biologically active agent, a chemical, a chemical compound, a surfactant, a steroid, a luminal-dilating agent, a luminal-contracting agent, an antibiotic or antifungal or antiviral agent, a protein, a nucleic acid or a polymer comprised of one or more nucleic acids, a macromolecule, a peptide, a polymer, or a biodegradable material.

24. A device, comprising:

a flexible hollow portion with an outer surface and an inner surface;

a plurality of movable parts coupled to the inner surface of the flexible hollow portion, the plurality of movable parts configured to contact a material and configured to generate a movable force on the material; and

a controller configured to provide an electric, magnetic, acoustic, optical or electromagnetic field to the plurality of movable parts for controlling the plurality of movable parts or the flexible hollow portion.

25. A system, comprising:

a device including a flexible hollow portion with an outer surface and an inner surface and wherein the flexible hollow portion is sized for placement in a location in a host;

a plurality of movable parts coupled to the inner surface of the flexible hollow portion, the plurality of movable parts operable as a group and configured for contacting and moving particles; and

an external or internal a controller configured to provide an electric, magnetic, acoustic, optical or electromagnetic field for controlling the device.

26. A device, comprising:

a flexible hollow portion with an outer surface and an inner surface;

a plurality of movable parts coupled to the inner surface of the flexible hollow portion, the plurality of movable parts configured to contact a material and including a control mechanism configured to induce controllable motion of the plurality of movable parts to generate a force for moving the material within the hollow portion; and

a reservoir for storing one or more of a drug, a medicinal agent, a therapeutic agent, a biologically active agent, a chemical, a chemical compound, a surfactant, a steroid, a luminal-dilating agent, a luminal-contracting agent, an antibiotic or antifungal or antiviral agent, a protein, a nucleic acid or a polymer comprised of one or more nucleic acids, a macromolecule, a peptide, a polymer, or a biodegradable material.

27. The device of claim 26, wherein the flexible hollow portion further comprises:

one or more movable parts coupled to the outer surface of the flexible hollow portion.

28. The device of claim 26, wherein the device further comprises:

a mechanism for powering the device.

29. The device of claim 28, wherein the mechanism for powering the device further comprises:

a mechanism for obtaining or storing energy.

30. A method of making a device, comprising:

forming a supporting passage implantable in a host;

coupling a plurality of moving parts to the supporting passage, wherein the plurality of moving parts are configured to contact a material and include a control mechanism configured to induce controllable motion of the plurality of movable parts to generate a force for moving the material within the hollow portion; and

sizing the supporting passage and the plurality of moving parts coupled to the supporting passage for placement in a location in the host.

31. The method of claim 30, wherein the method further comprises:

forming the supporting passage wherein at least a portion of the supporting passage is at least one of substantially flexible, compressible, or expansile.

32. The method of claim 30, wherein the method further comprises:

forming the supporting passage including a substantially expandable tubular or cylindrical part coupled to the plurality of moving parts.

33. The method of claim 30, wherein the method further comprises:

forming the supporting passage including an expandable mesh coupled to the plurality of moving parts.

34. The method of claim 30, wherein the method further comprises:

forming the supporting passage coupled to the plurality of moving parts configured for placement in the location in the host.

35. The method of claim 30, wherein the method further comprises:

forming a bifurcated supporting passage.

36. The method of claim 30, wherein the method further comprises:

forming the supporting passage or plurality of moving parts with one or more of a metal, silicon, polymer, plastic, inorganic, organic, or biodegradable material.

37. The method of claim 30, wherein the method further comprises:

coating at least a portion of the supporting passage or plurality of moving parts with a biocompatible material, polymer, biodegradable material, drug, medicinal agent, or therapeutic agent.

38. The method of claim 30, wherein the method further comprises:

producing a smooth surface in at least a portion of the interior of the supporting passage.

39. The method of claim 30, wherein the method further comprises:

making surface modifications in the exterior of the supporting passage operable for attaching to or positioning about the location in the host.

40. The method of claim 39, wherein the method further comprises:

forming surface modifications including grooves, contours, ridges, rings or bumps in the exterior of the supporting passage.

41. The method of claim 30, wherein the method further comprises:

forming the supporting passage or the plurality of moving parts including one or more of a gel, a hydrogel, a colloid, a polymer, an oscillating polymer, an electro-active polymer, a polymer, or a material coated with a biologically-compatible material.

42. The method of claim 30, wherein the method further comprises:

orienting the plurality of moving parts radially outward.

43. The method of claim 30, wherein the method further comprises:

configuring the plurality of moving parts to define a low-level gait or motion.

44. The method of claim 30, wherein the method further comprises:

configuring the plurality of moving parts to define a high-level gait or motion.

45. The method of claim 30, wherein the method further comprises:

operably-coupling an actuator, a motor, a biomolecular motor, or a device operable for providing motion to the plurality of moving parts.

46. The method of claim 30, wherein the method comprises:

forming the supporting passage with a custom size, shape, configuration, or dimension for placing in a trachea, a bronchi, a bronchial tree, a urogenital tract, a gastrointestinal tract, a pulmonary tract, a neurovascular system, or a vascular system.

47. The method of claim 30, wherein the method comprises:

forming the supporting passage with a custom size, shape, configuration, or dimension for replacing or functionally supplanting at least a portion of a trachea, a bronchi, a bronchial tree, a urogenital tract, a gastrointestinal tract, a pulmonary tract, a neurovascular system, or a vascular system.

48. The method of claim 30, wherein the method further comprises:

coupling an external control system to the plurality of moving parts or the supporting passage.

49. The method of claim 30, wherein the method further comprises:

including an external control system for remotely operating or manipulating the device.

50. The method of claim 30, wherein the method further comprises:

coupling a monitor to the supporting passage.

51. The method of claim 30, wherein the method further comprises:

coupling a debris-removing, debris-displacing or debris-relocating system to the supporting passage.

52. The method of claim 30, wherein the method further comprises:

providing a storage system for storing at least one of a drug, a medicinal agent, a therapeutic agent, a biologically active agent, a chemical, a chemical compound, a surfactant, a steroid, a luminal-dilating agent, a luminal-contracting agent, an antibiotic or antifungal or antiviral agent, a protein, a nucleic acid or a polymer comprised of one or more nucleic acids, a macromolecule, a peptide, a polymer, or a biodegradable material.

53. The method of claim 30, wherein the method further comprises:

coating at least a portion of the device with at least one of a drug, a medicinal agent, a therapeutic agent, a biologically active agent, a chemical, a chemical compound, a surfactant, a steroid, a luminal-dilating agent, a luminal-contracting agent, an antibiotic or antifungal or antiviral agent, a protein, a nucleic acid or a polymer comprised of one or more nucleic acids, a macromolecule, a peptide, a polymer, or a biodegradable material.

54. The method of claim 30, wherein the method further comprises:

including a mechanism for releasing one or more of a drug, a medicinal agent, a therapeutic agent, a biologically active agent, a chemical, a chemical compound, a surfactant, a steroid, a luminal-dilating a luminal-contracting agent, an antibiotic or antifungal or antiviral agent, a protein, a nucleic acid or a polymer comprised of one or more nucleic acids, a macromolecule, a peptide, a polymer, or a biodegradable material.

55. The method of claim 30, wherein the method further comprises:

storing energy internal or external to the device.

56. The method of claim 30, wherein the method further comprises:

providing a mechanism for obtaining power.

57. The method of claim 30, wherein the method further comprises:

coupling the plurality of moving parts to at least one of an interior wall or an exterior wall of the supporting passage.

58. A method of making a device, comprising:

forming a supporting passage implantable in a host;

coupling a plurality of moving parts to the supporting passage, the the plurality of movable parts configured to contact a material and including a control mechanism configured to induce controllable motion of the plurality of movable parts to generate a force for moving the material within the hollow portion;

sizing the supporting passage and the plurality of moving parts coupled to the supporting passage for placement in a location in the host; and

including an actuator operable for controlling the motion or direction of the one or more moving parts.

59. A method, comprising:

placing a hollow expandable device in a luminal portion of a recipient wherein the hollow expandable device includes an outer surface and an inner surface, wherein a plurality of moving parts are coupled to the inner surface, wherein the plurality of movable parts including a control mechanism configured to induce controllable motion of the plurality of movable parts to generate a force for moving material within the hollow portion;

positioning the hollow expandable device in the lumen of an organ; and

monitoring the hollow expandable device.

60. The method of claim 59, wherein the method further comprises:

adjusting, guiding, positioning, directing, or activating the hollow expandable device.

61. The method of claim 59, wherein the method further comprises:

removing the hollow expandable device.

62. The method of claim 59, wherein the method further comprises:

activating the one or more moving parts coupled to the hollow expandable device to move fluid, particles, fluidized particles, mucus, exudate or debris.

63. The method of claim 59, wherein the method further comprises:

placing the hollow expandable device in a trachea, a bronchi, a bronchial tree, a urogenital tract, a gastrointestinal tract, a pulmonary tract, a neurovascular system, or a vascular system.

64. The method of claim 59, wherein the method further comprises:

controlling a motion or directionality of the one or more of moving parts.

65. The method of claim 59, wherein the method further comprises:

adjusting the orientation of the one or more of moving parts.

66. The method of claim 59, wherein the method further comprises:

placing the hollow expandable device wherein the hollow expandable device has at least one fork.

67. The method of claim 66, wherein the method further comprises:

positioning the at least one fork.

68. The method of claim 59, wherein the method further comprises:

removing any debris.

69. The method of claim 59, wherein the method further comprises:

monitoring the hollow expandable device remotely.

70. The method of claim 59, wherein the method further comprises:

positioning the hollow expandable device and the one or more of moving parts remotely.

71. The method of claim 59, wherein the method further comprises:

charging the hollow expandable device.

72. The method of claim 59, wherein the method further comprises:

delivering a drug, a medicinal agent, a therapeutic agent, a biologically active agent, a chemical, a chemical compound, a surfactant, a steroid, a luminal-dilating agent, a luminal-contracting agent, an antibiotic or antifungal or antiviral agent, a protein, a nucleic acid or a polymer comprised of one or more nucleic acids, a macromolecule, a peptide, polymer, or a biodegradable material.

73. A method, comprising:

placing a hollow expandable device in a luminal portion of a host wherein the interior of the hollow expandable device is coupled to one or more moving parts, the one or more moving parts configured for contacting and moving particles;

positioning the hollow expandable device in the lumen of an organ;

monitoring the hollow expandable device; and

applying at least one of an external electric, magnetic, acoustic, optical or electromagnetic field for removing fluid, particles, fluidized particles, mucus, exudate or debris.

74. A method, comprising:

placing a hollow flexible device in a luminal portion of a host, the hollow flexible device having an interior configured to permit entry and exit of a material;

wherein the interior of the hollow flexible device includes one or more moving parts, the one or more moving parts configured to contact the material and to controllably move the material;

positioning the hollow flexible device in the lumen of an organ; and

applying at least one of an external electric, magnetic, acoustic, optical or electromagnetic field to the one or more movable parts.