Redox polymers
First Claim
1. An analyte sensor unit comprising:
- a housing adapted for placement on the surface of skin having a bottom surface for contacting with the skin and wherein the housing comprises;
an electrochemical-based sensor having a portion within the housing and a portion exterior to the housing and having a length to permit insertion of the second portion about 2 to about 7 mm beneath the surface of the skin, wherein the electrochemical-based sensor comprises;
an electrode comprising an analyte responsive enzyme and a mediator and wherein the mediator comprises;
a polymeric transition metal complex comprising;
a transition metal complex comprising at least one bidentate ligand;
a polymer backbone; and
at least one spacer attached to the polymer backbone, the at least one spacer comprising at least one non-cyclic functional group selected from the group consisting of —
(CRrRs)—
, —
O—
, —
S—
, —
C(O)O—
, —
S(O)2NRk—
, —
OC(O)NRm—
, —
OC(S)NRn, —
C(O)NRt—
, —
NRu—
, —
CRv═
N—
O—
, —
CRw═
NNRx— and
—
(SiRyRz)—
, and wherein Rr and Rs are independently hydrogen, chlorine, fluorine, or substituted or unsubstituted alkyl, alkoxy, alkenyl, or alkynyl, and Rk, Rm, Rn, Rt, Ru, Rv, Rw, Rx, Ry, and Rz are independently hydrogen or substituted or unsubstituted alkyl,wherein the at least one bidentate ligand of the transition metal complex is covalently coupled to the spacer.
2 Assignments
0 Petitions
Accused Products
Abstract
Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
-
Citations
21 Claims
-
1. An analyte sensor unit comprising:
a housing adapted for placement on the surface of skin having a bottom surface for contacting with the skin and wherein the housing comprises; an electrochemical-based sensor having a portion within the housing and a portion exterior to the housing and having a length to permit insertion of the second portion about 2 to about 7 mm beneath the surface of the skin, wherein the electrochemical-based sensor comprises; an electrode comprising an analyte responsive enzyme and a mediator and wherein the mediator comprises; a polymeric transition metal complex comprising; a transition metal complex comprising at least one bidentate ligand; a polymer backbone; and at least one spacer attached to the polymer backbone, the at least one spacer comprising at least one non-cyclic functional group selected from the group consisting of —
(CRrRs)—
, —
O—
, —
S—
, —
C(O)O—
, —
S(O)2NRk—
, —
OC(O)NRm—
, —
OC(S)NRn, —
C(O)NRt—
, —
NRu—
, —
CRv═
N—
O—
, —
CRw═
NNRx— and
—
(SiRyRz)—
, and wherein Rr and Rs are independently hydrogen, chlorine, fluorine, or substituted or unsubstituted alkyl, alkoxy, alkenyl, or alkynyl, and Rk, Rm, Rn, Rt, Ru, Rv, Rw, Rx, Ry, and Rz are independently hydrogen or substituted or unsubstituted alkyl,wherein the at least one bidentate ligand of the transition metal complex is covalently coupled to the spacer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
Specification