Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
First Claim
1. A surface coating, comprising:
- a primer coat that permits adhesion of eukaryotic cells thereto; and
a plurality of essentially spherical hydrogels attached to a said primer coat such that portions of said primer coat are exposed between said hydrogels, wherein each of said plurality of hydrogels has a diameter of less than one micron, and wherein at least some of said plurality of hydrogels are cell adhesion-resistant hydrogels, said cell adhesion-resistant hydrogels being in an unpatterned lateral distribution across a portion of said primer coat and spaced so as to permit adhesion of eukaryotic cells to said exposed portions of said primer coat, while resisting the adhesion of non-eukaryotic cells thereto.
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Accused Products
Abstract
A surface coating comprises a primer coat that permits adhesion of eukaryotic cells thereto, and a plurality of macromolecular structures attached to the primer coat. At least some of the macromolecular structures have a cell-resistant character, meaning that cells generally will not adhere to them. The macromolecular structures are distributed across an area of the primer coat so that the surface coating permits adhesion of the eukaryotic cells to the primer layer and resists the adhesion of non-eukaryotic cells. Typically, the primer coat comprises a self-assembled polymeric monolayer and the macromolecular structures comprise nanoscale hydrogels. Such surface coatings may be formed on articles of manufacture for insertion into the body, such as orthopedic devices.
99 Citations
13 Claims
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1. A surface coating, comprising:
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a primer coat that permits adhesion of eukaryotic cells thereto; and a plurality of essentially spherical hydrogels attached to a said primer coat such that portions of said primer coat are exposed between said hydrogels, wherein each of said plurality of hydrogels has a diameter of less than one micron, and wherein at least some of said plurality of hydrogels are cell adhesion-resistant hydrogels, said cell adhesion-resistant hydrogels being in an unpatterned lateral distribution across a portion of said primer coat and spaced so as to permit adhesion of eukaryotic cells to said exposed portions of said primer coat, while resisting the adhesion of non-eukaryotic cells thereto. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification